Department of Immunology and Cancer Research

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  • 2022

    Integrative single cell and spatial transcriptomics of colorectal cancer reveals multicellular functional units that support tumor progression

    Avraham-Davidi, I., Mages, S., Klughammer, J., Moriel, N., Imada, S., Hofree, M., Murray, E., Chen, J., Pelka, K., Mehta, A., Boland, G. M., Delorey, T., Caplan, L., Dionne, D., Tirosh, I., Hacohen, N., Chen, F., Yilmaz, O., Roper, J. & Rozenblatt-Rosen, O. & 2 others, Nitzan, M. & Regev, A., 1 Jan 2022, (bioRxiv).

    Research output: Working paper/preprint › Preprint

    Open Access

  • Multi-modal single-cell and whole-genome sequencing of minute, frozen specimens to propel clinical applications

    Wang, Y., Fan, J. L., Melms, J. C., Amin, A. D., Georgis, Y., Ho, P., Tagore, S., Abril-Rodríguez, G., Biermann, J., Hofree, M., Caprio, L., Berhe, S., Khan, S. A., Henick, B. S., Ribas, A., Taylor, A. M., Schwartz, G. K., Carvajal, R. D., Azizi, E. & Izar, B., 2022, (bioRxiv).

    Research output: Working paper/preprint › Preprint

    Open Access
  • 2021

    Metabolic Regulation of SARS-CoV-2 Infection

    Ehrlich, A., Ioannidis, K., Nasar, M., Alkian, I. A., Hofree, M., Tikva, S. S., Rainy, N., Houri, I., Cicero, A., Pavanello, C., Sirtori, C. R., Cohen, J. B., Chirinos, J. A., Deutsch, L., Gottlieb, A., Bar-Chaim, A., Shibolet, O., Maayan, S. L. & Nahmias, Y., 2021, (ResearchSquare).

    Research output: Working paper/preprint › Preprint

  • Multicellular immune hubs and their organization in MMRd and MMRp colorectal cancer

    Pelka, K., Hofree, M., Chen, J., Sarkizova, S., Pirl, J. D., Jorgji, V., Bejnood, A., Dionne, D., Ge, W. H., Xu, K. H., Chao, S. X., Zollinger, D. R., Lieb, D. J., Reeves, J. W., Fuhrman, C. A., Hoang, M. L., Delorey, T., Nguyen, L. T., Waldman, J. & Klapholz, M. & 51 others, Wakiro, I., Cohen, O., Smillie, C. S., Cuoco, M. S., Wu, J., Su, M.-J., Yeung, J., Vijaykumar, B., Magnuson, A. M., Asinovski, N., Moll, T., Goder-Reiser, M. N., Applebaum, A. S., Brais, L. K., DelloStritto, L. K., Denning, S. L., Phillips, S. T., Hill, E. K., Meehan, J. K., Frederick, D. T., Sharova, T., Kanodia, A., Todres, E. Z., Jané-Valbuena, J., Biton, M., Izar, B., Lambden, C. D., Clancy, T. E., Bleday, R., Melnitchouk, N., Irani, J., Kunitake, H., Berger, D. L., Srivastava, A., Hornick, J. L., Ogino, S., Rotem, A., Vigneau, S., Johnson, B. E., Corcoran, R. B., Sharpe, A. H., Kuchroo, V. K., Ng, K., Giannakis, M., Nieman, L. T., Boland, G. M., Aguirre, A. J., Anderson, A. C., Rozenblatt-Rosen, O., Regev, A. & Hacohen, N., 2021, (bioRxiv).

    Research output: Working paper/preprint › Preprint

    Open Access

  • Parental-fetal interplay of immune genes leads to intrauterine growth restriction

    Kaur, G., Porter, C. B. M., Ashenberg, O., Lee, J., Riesenfeld, S. J., Hofree, M., Aggelakopoulou, M., Subramanian, A., Kuttikkatte, S. B., Attfield, K. E., Desel, C. A. E., Davies, J. L., Evans, H. G., Davidi, I. A., Nguyen, L. T., Dionne, D. A., Neumann, A. E., Jensen, L. T., Barber, T. R. & Soilleux, E. & 5 others, Carrington, M., McVean, G., Rozenblatt-Rosen, O., Regev, A. & Fugger, L., 2021, (bioRxiv).

    Research output: Working paper/preprint › Preprint

    Open Access
  • 2020

    The SARS-CoV-2 Transcriptional Metabolic Signature in Lung Epithelium

    Ehrlich, A., Uhl, S., Ioannidis, K., Hofree, M., tenOever, B. R. & Nahmias, Y., 2020, (SSRN).

    Research output: Working paper/preprint › Preprint

    Open Access
  • 2019

    A cellular taxonomy of the bone marrow stroma in homeostasis and leukemia demonstrates cancer-crosstalk with stroma to impair normal tissue function

    Ninib, B., Dariusz, P., Kowalczyk, M. S., Youmna, K., Nicolas, S., Karin, G., Francois, M., Marcin, T., Matan, H., Danielle, D., Ani, P., Dongjun, L., Orit, R.-R., Aviv, R. & Scadden, D. T., 1 Jan 2019, (bioRxiv).

    Research output: Working paper/preprint › Preprint

    Open Access
  • 2018

    Synthetic essentiality of metabolic regulator PDHK1 in PTEN-deficient cells and cancers

    Chatterjee, N., Pazarentzos, E., Hrustanovic, G., Lin, L., Verschueren, E., Johnson, J. R., Hofree, M., Yan, J. J., Olivas, V., Newton, B. W., Dollen, J. V., Earnshaw, C. H., Flanagan, J., Chan, E., Asthana, S., Ideker, T., Wu, W., Mayekar, M. K., Suzuki, J. & Barad, B. & 7 others, Kirichok, Y., Fraser, J., Weiss, W. A., Krogan, N. J., Tulpule, A., Sabnis, A. J. & Bivona, T. G., 2018, (bioRxiv).

    Research output: Working paper/preprint › Preprint

    Open Access