α-Amino boronates as cyanoborane complexes: Crystal structure and inhibition properties for the serine proteases: α-chymotrypsin and trypsin

Amal Shibli, Reem Smoum, Israel Goldberg, Abraham Rubinstein, Morris Srebnik*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

The first examples of α-amino boronate complexes stabilized by amino cyanoborane complexation were tested as trypsin and chymotrypsin inhibitors, and they showed moderate inhibition. The structure of compound 1 that contains two different boron atoms reveals that the geometry around the boron atom in the cyano group is tetrahedral, whereas a trigonal planar geometry exists around the boron atom attached to two oxygen atoms and a carbon atom.

Original languageAmerican English
Pages (from-to)459-462
Number of pages4
JournalApplied Organometallic Chemistry
Volume20
Issue number7
DOIs
StatePublished - Jul 2006

Keywords

  • Amine cyanoborane
  • Biological properties
  • Chymotrypsin
  • Crystal structure
  • Serine proteases
  • Trypsin
  • α-amino boronic acid

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