α-Amino boronates as cyanoborane complexes: Crystal structure and inhibition properties for the serine proteases: α-chymotrypsin and trypsin

Amal Shibli; Reem Smoum; Israel Goldberg; Abraham Rubinstein; Morris Srebnik

doi:10.1002/aoc.1095

α-Amino boronates as cyanoborane complexes: Crystal structure and inhibition properties for the serine proteases: α-chymotrypsin and trypsin

Amal Shibli
, Reem Smoum
, Israel Goldberg
, Abraham Rubinstein
, Morris Srebnik^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The first examples of α-amino boronate complexes stabilized by amino cyanoborane complexation were tested as trypsin and chymotrypsin inhibitors, and they showed moderate inhibition. The structure of compound 1 that contains two different boron atoms reveals that the geometry around the boron atom in the cyano group is tetrahedral, whereas a trigonal planar geometry exists around the boron atom attached to two oxygen atoms and a carbon atom.

Original language	English
Pages (from-to)	459-462
Number of pages	4
Journal	Applied Organometallic Chemistry
Volume	20
Issue number	7
DOIs	https://doi.org/10.1002/aoc.1095
State	Published - Jul 2006

Keywords

Amine cyanoborane
Biological properties
Chymotrypsin
Crystal structure
Serine proteases
Trypsin
α-amino boronic acid

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10.1002/aoc.1095

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abstract = "The first examples of α-amino boronate complexes stabilized by amino cyanoborane complexation were tested as trypsin and chymotrypsin inhibitors, and they showed moderate inhibition. The structure of compound 1 that contains two different boron atoms reveals that the geometry around the boron atom in the cyano group is tetrahedral, whereas a trigonal planar geometry exists around the boron atom attached to two oxygen atoms and a carbon atom.",

keywords = "Amine cyanoborane, Biological properties, Chymotrypsin, Crystal structure, Serine proteases, Trypsin, α-amino boronic acid",

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AU - Goldberg, Israel

AU - Rubinstein, Abraham

AU - Srebnik, Morris

PY - 2006/7

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AB - The first examples of α-amino boronate complexes stabilized by amino cyanoborane complexation were tested as trypsin and chymotrypsin inhibitors, and they showed moderate inhibition. The structure of compound 1 that contains two different boron atoms reveals that the geometry around the boron atom in the cyano group is tetrahedral, whereas a trigonal planar geometry exists around the boron atom attached to two oxygen atoms and a carbon atom.

KW - Amine cyanoborane

KW - Biological properties

KW - Chymotrypsin

KW - Crystal structure

KW - Serine proteases

KW - Trypsin

KW - α-amino boronic acid

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JO - Applied Organometallic Chemistry

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ER -

α-Amino boronates as cyanoborane complexes: Crystal structure and inhibition properties for the serine proteases: α-chymotrypsin and trypsin

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Keywords

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