Abstract
Vitamin D3 deficient (D-) mice show a depressed inflammatory response and both inflammatory peritoneal macrophages and bone marrow polymorphonuclear leukocytes of D- mice exhibit a decreased spontaneous migration under agarose. The impaired phagocytic response of peritoneal macrophages from D- mice can be corrected by incubation with 1,25-dihydroxyvitamin D3 and is not affected by interaction with other vitamin D3 metabolites. Transfer of mice from the D- to the D+ state results in correction of both the inflammatory and the phagocytic response. Intactness of phagocyte function is thus directly dependent on vitamin D3 metabolism.
Original language | English |
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Pages (from-to) | 673-676 |
Number of pages | 4 |
Journal | Calcified Tissue International |
Volume | 33 |
Issue number | 1 |
DOIs | |
State | Published - Dec 1981 |
Externally published | Yes |