1,25-Dihydroxyvitamin D3 and the regulation of macrophage function

Z. Bar-Shavit, D. Noff, S. Edelstein, M. Meyer, S. Shibolet, R. Goldman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

133 Scopus citations

Abstract

Vitamin D3 deficient (D-) mice show a depressed inflammatory response and both inflammatory peritoneal macrophages and bone marrow polymorphonuclear leukocytes of D- mice exhibit a decreased spontaneous migration under agarose. The impaired phagocytic response of peritoneal macrophages from D- mice can be corrected by incubation with 1,25-dihydroxyvitamin D3 and is not affected by interaction with other vitamin D3 metabolites. Transfer of mice from the D- to the D+ state results in correction of both the inflammatory and the phagocytic response. Intactness of phagocyte function is thus directly dependent on vitamin D3 metabolism.

Original languageEnglish
Pages (from-to)673-676
Number of pages4
JournalCalcified Tissue International
Volume33
Issue number1
DOIs
StatePublished - Dec 1981
Externally publishedYes

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