1,25-Dihydroxyvitamin D3 enhances prostaglandin E2 production by monocytes. A mechanism which partially accounts for the antiproliferative effect of 1,25(OH)2D3 on lymphocytes

R. Koren; A. Ravid; C. Rotem; E. Shohami; U. A. Liberman; A. Novogrodsky

doi:10.1016/0014-5793(86)80876-6

1,25-Dihydroxyvitamin D₃ enhances prostaglandin E₂ production by monocytes. A mechanism which partially accounts for the antiproliferative effect of 1,25(OH)₂D₃ on lymphocytes

R. Koren^*, A. Ravid, C. Rotem, E. Shohami, U. A. Liberman, A. Novogrodsky

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

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Abstract

Partial removal of monocytes from human peripheral blood mononuclear cells, or the addition of indomethacin. reduced the antiproliferative effect of 1,25(OH)₂D₃ on mitogen-stimulated mononuclear cells. Addition of 1,25(OH)₂D₃ (1nM) to mitogen-stimulated mononuclear cells caused a 2-4-fold increase in prostaglandin E₂ production during the second day of culture. The inhibitory effect of 1,25(OH)₂D₃ on lymphocyte proliferation is greatly augmented up to 7-fold in the presence of prostaglandin E₂. We conclude that monocytes are involved in the inhibitory effect of 1,25(OH)₂D₃ on the mitogenic stimulation of human lymphocytes and that their action is probably mediated by prostaglandins.

Original language	English
Pages (from-to)	113-116
Number of pages	4
Journal	FEBS Letters
Volume	205
Issue number	1
DOIs	https://doi.org/10.1016/0014-5793(86)80876-6
State	Published - 1 Sep 1986

Keywords

1,25-Dihydroxy vitamin D
Lymphocyte activation
Monocyte
Prostaglandin E

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10.1016/0014-5793(86)80876-6

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title = "1,25-Dihydroxyvitamin D3 enhances prostaglandin E2 production by monocytes. A mechanism which partially accounts for the antiproliferative effect of 1,25(OH)2D3 on lymphocytes",

abstract = "Partial removal of monocytes from human peripheral blood mononuclear cells, or the addition of indomethacin. reduced the antiproliferative effect of 1,25(OH)2D3 on mitogen-stimulated mononuclear cells. Addition of 1,25(OH)2D3 (1nM) to mitogen-stimulated mononuclear cells caused a 2-4-fold increase in prostaglandin E2 production during the second day of culture. The inhibitory effect of 1,25(OH)2D3 on lymphocyte proliferation is greatly augmented up to 7-fold in the presence of prostaglandin E2. We conclude that monocytes are involved in the inhibitory effect of 1,25(OH)2D3 on the mitogenic stimulation of human lymphocytes and that their action is probably mediated by prostaglandins.",

keywords = "1,25-Dihydroxy vitamin D, Lymphocyte activation, Monocyte, Prostaglandin E",

author = "R. Koren and A. Ravid and C. Rotem and E. Shohami and Liberman, {U. A.} and A. Novogrodsky",

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AU - Koren, R.

AU - Ravid, A.

AU - Rotem, C.

AU - Shohami, E.

AU - Liberman, U. A.

AU - Novogrodsky, A.

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AB - Partial removal of monocytes from human peripheral blood mononuclear cells, or the addition of indomethacin. reduced the antiproliferative effect of 1,25(OH)2D3 on mitogen-stimulated mononuclear cells. Addition of 1,25(OH)2D3 (1nM) to mitogen-stimulated mononuclear cells caused a 2-4-fold increase in prostaglandin E2 production during the second day of culture. The inhibitory effect of 1,25(OH)2D3 on lymphocyte proliferation is greatly augmented up to 7-fold in the presence of prostaglandin E2. We conclude that monocytes are involved in the inhibitory effect of 1,25(OH)2D3 on the mitogenic stimulation of human lymphocytes and that their action is probably mediated by prostaglandins.

KW - 1,25-Dihydroxy vitamin D

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1,25-Dihydroxyvitamin D₃ enhances prostaglandin E₂ production by monocytes. A mechanism which partially accounts for the antiproliferative effect of 1,25(OH)₂D₃ on lymphocytes

Abstract

Keywords

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