TY - JOUR
T1 - 2-Arachidonoylglycerol, an endogenous cannabinoid receptor agonist, in various rat tissues during the evolution of experimental cholestatic liver disease
AU - Avraham, Yosefa
AU - Magen, Iddo
AU - Zolotarev, Olga
AU - Vorobiav, Lia
AU - Nachmias, Avital
AU - Pappo, Orit
AU - Ilan, Yaron
AU - Berry, Elliot M.
AU - Ackerman, Zvi
PY - 2008/7
Y1 - 2008/7
N2 - Background/Aim: Changes in tissue levels of 2-arachidonoylglycerol (2-AG), an endocannabinoid, during the evolution of bile duct ligation (BDL) may indicate that endocannabinoids have a role in the hemodynamic changes that occur in this condition. Methods: 2-AG levels, in various organs and vascular beds of BDL rats, 2 and 4 weeks post surgery, were determined. Untouched and sham-operated (SO) rats were used as controls. Results: 2-AG content of a specific organ was not a static finding and depended on the rat's age, the time from the surgical procedure and the type of procedure. The most pronounced changes were observed in BDL rats 4 weeks post surgery. In these rats, hepatic, pulmonary, cardiac and renal medullary and papillary 2-AG levels were highest observed. No changes in splenic, aortic and renal cortical 2-AG levels were observed. In addition a stepwise increase in 2-AG levels from the cortex to the papilla was detected and was followed by a decrease in creatinine clearance. Conclusions: 2-AG probably has a role in the pathophysiologic changes in the liver, heart, lung and kidney that follows BDL.
AB - Background/Aim: Changes in tissue levels of 2-arachidonoylglycerol (2-AG), an endocannabinoid, during the evolution of bile duct ligation (BDL) may indicate that endocannabinoids have a role in the hemodynamic changes that occur in this condition. Methods: 2-AG levels, in various organs and vascular beds of BDL rats, 2 and 4 weeks post surgery, were determined. Untouched and sham-operated (SO) rats were used as controls. Results: 2-AG content of a specific organ was not a static finding and depended on the rat's age, the time from the surgical procedure and the type of procedure. The most pronounced changes were observed in BDL rats 4 weeks post surgery. In these rats, hepatic, pulmonary, cardiac and renal medullary and papillary 2-AG levels were highest observed. No changes in splenic, aortic and renal cortical 2-AG levels were observed. In addition a stepwise increase in 2-AG levels from the cortex to the papilla was detected and was followed by a decrease in creatinine clearance. Conclusions: 2-AG probably has a role in the pathophysiologic changes in the liver, heart, lung and kidney that follows BDL.
UR - http://www.scopus.com/inward/record.url?scp=51449083345&partnerID=8YFLogxK
U2 - 10.1016/j.plefa.2008.07.003
DO - 10.1016/j.plefa.2008.07.003
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C2 - 18771906
AN - SCOPUS:51449083345
SN - 0952-3278
VL - 79
SP - 35
EP - 40
JO - Prostaglandins Leukotrienes and Essential Fatty Acids
JF - Prostaglandins Leukotrienes and Essential Fatty Acids
IS - 1-2
ER -
