Abstract
The signaling lymphocytic activation molecule (SLAM) family of receptors (SLAMF) is a group of receptors belonging to the CD2 family. It is composed of several members expressed on many hematopoietic cells. Most of the receptors interact in a homophilic fashion with neighboring cells. Their distribution and binding properties, together with their ability to function as both activating and inhibitory receptors, put them as key players in the immune system regulation. Several SLAM family receptors have been extensively investigated. This review mainly focuses on CD244 (2B4 or SLAMF4,) and CD48, particularly as expressed by the key cells of allergy, mast cells and eosinophils.
Original language | American English |
---|---|
Pages (from-to) | 64-68 |
Number of pages | 5 |
Journal | Clinical Immunology |
Volume | 204 |
DOIs | |
State | Published - Jul 2019 |
Bibliographical note
Funding Information:Francesca Levi-Schaffer is affiliated with the Adolph and Klara Brettler Center for Research in Molecular Pharmacology and Therapeutics at the Hebrew University. This work was funded by Israel Science Foundation 472/15, the Aimwell Charitable Trust (UK), Emalie Gutterman Memorial Endowed Fund for COPD related research (USA) and The Rosetrees Trust (UK).
Funding Information:
This work was funded by Israel Science Foundation 472/15 , the Aimwell Charitable Trust (UK) , Emalie Gutterman Memorial Endowed Fund for COPD related research (USA) and The Rosetrees Trust (UK) .
Publisher Copyright:
© 2018 Elsevier Inc.
Keywords
- 2B4
- Allergic Effector Unit (AEU)
- Allergy
- CD48
- Eosinophils
- Mast cells
- SLAM receptors