2B4 and CD48: A powerful couple of the immune system

Hadas Pahima; Pier Giorgio Puzzovio; Francesca Levi-Schaffer

doi:10.1016/j.clim.2018.10.014

2B4 and CD48: A powerful couple of the immune system

Hadas Pahima, Pier Giorgio Puzzovio, Francesca Levi-Schaffer^*

^*Corresponding author for this work

School of Pharmacy

Research output: Contribution to journal › Review article › peer-review

23 Scopus citations

Abstract

The signaling lymphocytic activation molecule (SLAM) family of receptors (SLAMF) is a group of receptors belonging to the CD2 family. It is composed of several members expressed on many hematopoietic cells. Most of the receptors interact in a homophilic fashion with neighboring cells. Their distribution and binding properties, together with their ability to function as both activating and inhibitory receptors, put them as key players in the immune system regulation. Several SLAM family receptors have been extensively investigated. This review mainly focuses on CD244 (2B4 or SLAMF4,) and CD48, particularly as expressed by the key cells of allergy, mast cells and eosinophils.

Original language	American English
Pages (from-to)	64-68
Number of pages	5
Journal	Clinical Immunology
Volume	204
DOIs	https://doi.org/10.1016/j.clim.2018.10.014
State	Published - Jul 2019

Bibliographical note

Funding Information:
Francesca Levi-Schaffer is affiliated with the Adolph and Klara Brettler Center for Research in Molecular Pharmacology and Therapeutics at the Hebrew University. This work was funded by Israel Science Foundation 472/15, the Aimwell Charitable Trust (UK), Emalie Gutterman Memorial Endowed Fund for COPD related research (USA) and The Rosetrees Trust (UK).

Funding Information:
This work was funded by Israel Science Foundation 472/15 , the Aimwell Charitable Trust (UK) , Emalie Gutterman Memorial Endowed Fund for COPD related research (USA) and The Rosetrees Trust (UK) .

Publisher Copyright:
© 2018 Elsevier Inc.

Keywords

2B4
Allergic Effector Unit (AEU)
Allergy
CD48
Eosinophils
Mast cells
SLAM receptors

Access to Document

10.1016/j.clim.2018.10.014

Cite this

@article{c8c525285faa447992bffebd8277cd1d,

title = "2B4 and CD48: A powerful couple of the immune system",

abstract = "The signaling lymphocytic activation molecule (SLAM) family of receptors (SLAMF) is a group of receptors belonging to the CD2 family. It is composed of several members expressed on many hematopoietic cells. Most of the receptors interact in a homophilic fashion with neighboring cells. Their distribution and binding properties, together with their ability to function as both activating and inhibitory receptors, put them as key players in the immune system regulation. Several SLAM family receptors have been extensively investigated. This review mainly focuses on CD244 (2B4 or SLAMF4,) and CD48, particularly as expressed by the key cells of allergy, mast cells and eosinophils.",

keywords = "2B4, Allergic Effector Unit (AEU), Allergy, CD48, Eosinophils, Mast cells, SLAM receptors",

author = "Hadas Pahima and Puzzovio, {Pier Giorgio} and Francesca Levi-Schaffer",

note = "Funding Information: Francesca Levi-Schaffer is affiliated with the Adolph and Klara Brettler Center for Research in Molecular Pharmacology and Therapeutics at the Hebrew University. This work was funded by Israel Science Foundation 472/15, the Aimwell Charitable Trust (UK), Emalie Gutterman Memorial Endowed Fund for COPD related research (USA) and The Rosetrees Trust (UK). Funding Information: This work was funded by Israel Science Foundation 472/15 , the Aimwell Charitable Trust (UK) , Emalie Gutterman Memorial Endowed Fund for COPD related research (USA) and The Rosetrees Trust (UK) . Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = jul,

doi = "10.1016/j.clim.2018.10.014",

language = "American English",

volume = "204",

pages = "64--68",

journal = "Clinical Immunology",

issn = "1521-6616",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - 2B4 and CD48

T2 - A powerful couple of the immune system

AU - Pahima, Hadas

AU - Puzzovio, Pier Giorgio

AU - Levi-Schaffer, Francesca

N1 - Funding Information: Francesca Levi-Schaffer is affiliated with the Adolph and Klara Brettler Center for Research in Molecular Pharmacology and Therapeutics at the Hebrew University. This work was funded by Israel Science Foundation 472/15, the Aimwell Charitable Trust (UK), Emalie Gutterman Memorial Endowed Fund for COPD related research (USA) and The Rosetrees Trust (UK). Funding Information: This work was funded by Israel Science Foundation 472/15 , the Aimwell Charitable Trust (UK) , Emalie Gutterman Memorial Endowed Fund for COPD related research (USA) and The Rosetrees Trust (UK) . Publisher Copyright: © 2018 Elsevier Inc.

PY - 2019/7

Y1 - 2019/7

N2 - The signaling lymphocytic activation molecule (SLAM) family of receptors (SLAMF) is a group of receptors belonging to the CD2 family. It is composed of several members expressed on many hematopoietic cells. Most of the receptors interact in a homophilic fashion with neighboring cells. Their distribution and binding properties, together with their ability to function as both activating and inhibitory receptors, put them as key players in the immune system regulation. Several SLAM family receptors have been extensively investigated. This review mainly focuses on CD244 (2B4 or SLAMF4,) and CD48, particularly as expressed by the key cells of allergy, mast cells and eosinophils.

AB - The signaling lymphocytic activation molecule (SLAM) family of receptors (SLAMF) is a group of receptors belonging to the CD2 family. It is composed of several members expressed on many hematopoietic cells. Most of the receptors interact in a homophilic fashion with neighboring cells. Their distribution and binding properties, together with their ability to function as both activating and inhibitory receptors, put them as key players in the immune system regulation. Several SLAM family receptors have been extensively investigated. This review mainly focuses on CD244 (2B4 or SLAMF4,) and CD48, particularly as expressed by the key cells of allergy, mast cells and eosinophils.

KW - 2B4

KW - Allergic Effector Unit (AEU)

KW - Allergy

KW - CD48

KW - Eosinophils

KW - Mast cells

KW - SLAM receptors

UR - http://www.scopus.com/inward/record.url?scp=85055735855&partnerID=8YFLogxK

U2 - 10.1016/j.clim.2018.10.014

DO - 10.1016/j.clim.2018.10.014

M3 - Review article

C2 - 30366105

AN - SCOPUS:85055735855

SN - 1521-6616

VL - 204

SP - 64

EP - 68

JO - Clinical Immunology

JF - Clinical Immunology

ER -

2B4 and CD48: A powerful couple of the immune system

Abstract

Bibliographical note

Keywords

Access to Document

Other files and links

Fingerprint

Cite this