2‐Nitro‐4‐Methoxyphenylsulfenyl—A New Protecting Group for the Amino Nitrogen

Y. Wolman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

The use of 2‐nitro‐4‐methoxy‐phenylsulfenyl‐(I) as an amino protecting group which is extremely sensitive towards electrophilic attack in the synthesis of amino penicillins (amino‐penicillin and DL‐α‐amino‐benzylpenicillin) is described. Synthesis of few protected dipeptides (2‐nitro‐4‐methoxyphenylsulfenyl‐L‐phenylalanyl‐L‐valine, 2‐nitro‐4‐methoxyphenylsulfenyl‐L‐phenylalanyl‐L‐phenylalanine and 2‐nitro‐4‐methoxyphenylsulfenyl‐L‐valyl‐L‐phenylalanine) demonstrates the use of the protecting group in peptide synthesis.

Original languageEnglish
Pages (from-to)231-236
Number of pages6
JournalIsrael Journal of Chemistry
Volume5
Issue number5
DOIs
StatePublished - 1967

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