3D monitoring and control of microbubble cavitation for gene delivery

Xiran Cai; Josquin Foiret; Joseph Roth; Zulma Gazit; Gadi Pelled; Dan Gazit; Katherine W. Ferrara

doi:10.1109/ULTSYM.2019.8926184

3D monitoring and control of microbubble cavitation for gene delivery

Xiran Cai, Josquin Foiret, Joseph Roth, Zulma Gazit, Gadi Pelled, Dan Gazit, Katherine W. Ferrara

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

2 Scopus citations

Abstract

Previous work showed promising results in healing large bone fractures using ultrasound-mediated gene delivery. To further improve current gene therapy for bone fractures, we aim to develop the capability to monitor and control microbubble (MB) cavitation in 3D. In this work, a generic 1024-channel 3D real-time ultrasound tomography system is introduced. B-mode, contrast-enhanced imaging and passive acoustic mapping have been implemented. Volumetric ultrasound imaging uses a motion controller to realize 3D imaging capabilities. Half wavelength spatial resolution and 150 dB dynamic range with improved CNR have been achieved with our current setup. With incoherent compounding, MB cavitation can be localized in a circular region with a diameter of ~ 2.5 mm. Arrays of different aperture size and frequency can be assembled in personalized geometries (e.g. full ring, half ring) and integrated into our tomography system. The system will be applied broadly, including creating the ability to heal bone defects using MB-based gene delivery.

Original language	English
Title of host publication	2019 IEEE International Ultrasonics Symposium, IUS 2019
Publisher	IEEE Computer Society
Pages	888-890
Number of pages	3
ISBN (Electronic)	9781728145969
DOIs	https://doi.org/10.1109/ULTSYM.2019.8926184
State	Published - Oct 2019
Externally published	Yes
Event	2019 IEEE International Ultrasonics Symposium, IUS 2019 - Glasgow, United Kingdom Duration: 6 Oct 2019 → 9 Oct 2019

Publication series

Name	IEEE International Ultrasonics Symposium, IUS
Volume	2019-October
ISSN (Print)	1948-5719
ISSN (Electronic)	1948-5727

Conference

Conference	2019 IEEE International Ultrasonics Symposium, IUS 2019
Country/Territory	United Kingdom
City	Glasgow
Period	6/10/19 → 9/10/19

Bibliographical note

Publisher Copyright:
© 2019 IEEE.

Keywords

Tomography
dynamic range
gene delivery
image resolution
microbubble cavitation
passive acoustic mapping

Access to Document

10.1109/ULTSYM.2019.8926184

Cite this

Cai, X., Foiret, J., Roth, J., Gazit, Z., Pelled, G., Gazit, D., & Ferrara, K. W. (2019). 3D monitoring and control of microbubble cavitation for gene delivery. In 2019 IEEE International Ultrasonics Symposium, IUS 2019 (pp. 888-890). Article 8926184 (IEEE International Ultrasonics Symposium, IUS; Vol. 2019-October). IEEE Computer Society. https://doi.org/10.1109/ULTSYM.2019.8926184

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title = "3D monitoring and control of microbubble cavitation for gene delivery",

abstract = "Previous work showed promising results in healing large bone fractures using ultrasound-mediated gene delivery. To further improve current gene therapy for bone fractures, we aim to develop the capability to monitor and control microbubble (MB) cavitation in 3D. In this work, a generic 1024-channel 3D real-time ultrasound tomography system is introduced. B-mode, contrast-enhanced imaging and passive acoustic mapping have been implemented. Volumetric ultrasound imaging uses a motion controller to realize 3D imaging capabilities. Half wavelength spatial resolution and 150 dB dynamic range with improved CNR have been achieved with our current setup. With incoherent compounding, MB cavitation can be localized in a circular region with a diameter of ~ 2.5 mm. Arrays of different aperture size and frequency can be assembled in personalized geometries (e.g. full ring, half ring) and integrated into our tomography system. The system will be applied broadly, including creating the ability to heal bone defects using MB-based gene delivery.",

keywords = "Tomography, dynamic range, gene delivery, image resolution, microbubble cavitation, passive acoustic mapping",

author = "Xiran Cai and Josquin Foiret and Joseph Roth and Zulma Gazit and Gadi Pelled and Dan Gazit and Ferrara, {Katherine W.}",

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year = "2019",

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doi = "10.1109/ULTSYM.2019.8926184",

language = "אנגלית",

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Cai, X, Foiret, J, Roth, J, Gazit, Z, Pelled, G, Gazit, D & Ferrara, KW 2019, 3D monitoring and control of microbubble cavitation for gene delivery. in 2019 IEEE International Ultrasonics Symposium, IUS 2019., 8926184, IEEE International Ultrasonics Symposium, IUS, vol. 2019-October, IEEE Computer Society, pp. 888-890, 2019 IEEE International Ultrasonics Symposium, IUS 2019, Glasgow, United Kingdom, 6/10/19. https://doi.org/10.1109/ULTSYM.2019.8926184

3D monitoring and control of microbubble cavitation for gene delivery. / Cai, Xiran; Foiret, Josquin; Roth, Joseph et al.
2019 IEEE International Ultrasonics Symposium, IUS 2019. IEEE Computer Society, 2019. p. 888-890 8926184 (IEEE International Ultrasonics Symposium, IUS; Vol. 2019-October).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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3D monitoring and control of microbubble cavitation for gene delivery

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Keywords

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