4S oop RNA is a leader sequence for the immunity-establishment transcription in coliphage λ

A. Honigman*, S. L. Hu, R. Chase, W. Szybalski

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Scopus citations

Abstract

oop RNA, which is initiated at the po promoter and is 81 nucleotides long, can function as a leader sequence for the λ immunity establishment transcription, previously believed to originate at a special promoter pre located in the y region. Thus, oop RNA seems to have a dual role, either favouring the lytic cycle as a primer for the initiation of λ DNA replication, or leading to the establishment of lysogeny when elongated into the imm transcript, which directs synthesis of the repressor.

Original languageEnglish
Pages (from-to)112-116
Number of pages5
JournalNature
Volume262
Issue number5564
DOIs
StatePublished - 1976
Externally publishedYes

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