TY - JOUR
T1 - 5 Iron metabolism in inflammation
AU - Konijn, Abraham M.
PY - 1994/12
Y1 - 1994/12
N2 - Alteration in iron metabolism is one of the proposed mechanisms underlying the anaemia of inflammation and chronic disease, the most common disorder in hospitalized patients. Iron metabolism parameters in inflammatory disease are characterized by blockage of tissue iron release, decreased serum iron and total iron binding capacity and an elevated serum ferritin level, reflecting augmented ferritin synthesis as part of the acutephase response. The altered iron metabolism in inflammation is proposed to be a part of the host defence mechanism against invading pathogens and tumor cells and is suggested to be mediated by inflammatory cytokines and NO.
AB - Alteration in iron metabolism is one of the proposed mechanisms underlying the anaemia of inflammation and chronic disease, the most common disorder in hospitalized patients. Iron metabolism parameters in inflammatory disease are characterized by blockage of tissue iron release, decreased serum iron and total iron binding capacity and an elevated serum ferritin level, reflecting augmented ferritin synthesis as part of the acutephase response. The altered iron metabolism in inflammation is proposed to be a part of the host defence mechanism against invading pathogens and tumor cells and is suggested to be mediated by inflammatory cytokines and NO.
UR - http://www.scopus.com/inward/record.url?scp=0028609224&partnerID=8YFLogxK
U2 - 10.1016/S0950-3536(05)80127-1
DO - 10.1016/S0950-3536(05)80127-1
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C2 - 7881156
AN - SCOPUS:0028609224
SN - 0950-3536
VL - 7
SP - 829
EP - 849
JO - Bailliere's Clinical Haematology
JF - Bailliere's Clinical Haematology
IS - 4
ER -
