9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models

Rachel Twitto-Greenberg; Sigal Liraz-Zaltsman; Daniel M. Michaelson; Ori Liraz; Irit Lubitz; Dana Atrakchi-Baranes; Chen Shemesh; Uri Ashery; Itzik Cooper; Ayelet Harari; Dror Harats; Michal Schnaider-Beeri; Aviv Shaish

doi:10.1016/j.neurobiolaging.2023.09.005

9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models

Rachel Twitto-Greenberg, Sigal Liraz-Zaltsman, Daniel M. Michaelson, Ori Liraz, Irit Lubitz, Dana Atrakchi-Baranes, Chen Shemesh, Uri Ashery, Itzik Cooper, Ayelet Harari, Dror Harats, Michal Schnaider-Beeri, Aviv Shaish^*

^*Corresponding author for this work

School of Pharmacy

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1 Scopus citations

Abstract

A significant progressive decline in beta-carotene (βC) levels in the brain is associated with cognitive impairment and a higher prevalence of Alzheimer's disease (AD). In this study, we investigated whether the administration of 9-cis beta-carotene (9CBC)-rich powder of the alga Dunaliella bardawil, the best-known source of βC in nature, inhibits the development of AD-like neuropathology and cognitive deficits. We demonstrated that in 3 AD mouse models, Tg2576, 5xFAD, and apoE4, 9CBC treatment improved long- and short-term memory, decreased neuroinflammation, and reduced the prevalence of β-amyloid plaques and tau hyperphosphorylation. These findings suggest that 9CBC has the potential to be an effective preventive and symptomatic AD therapy.

Original language	English
Pages (from-to)	16-27
Number of pages	12
Journal	Neurobiology of Aging
Volume	133
DOIs	https://doi.org/10.1016/j.neurobiolaging.2023.09.005
State	Published - Jan 2024

Bibliographical note

Publisher Copyright:
© 2023 Elsevier Inc.

Keywords

9-cis beta-carotene
Alzheimer's disease
Beta-carotene
Cognition
Dunaliella
Inflammation

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Twitto-Greenberg, R., Liraz-Zaltsman, S., Michaelson, D. M., Liraz, O., Lubitz, I., Atrakchi-Baranes, D., Shemesh, C., Ashery, U., Cooper, I., Harari, A., Harats, D., Schnaider-Beeri, M., & Shaish, A. (2024). 9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models. Neurobiology of Aging, 133, 16-27. https://doi.org/10.1016/j.neurobiolaging.2023.09.005

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title = "9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models",

abstract = "A significant progressive decline in beta-carotene (βC) levels in the brain is associated with cognitive impairment and a higher prevalence of Alzheimer's disease (AD). In this study, we investigated whether the administration of 9-cis beta-carotene (9CBC)-rich powder of the alga Dunaliella bardawil, the best-known source of βC in nature, inhibits the development of AD-like neuropathology and cognitive deficits. We demonstrated that in 3 AD mouse models, Tg2576, 5xFAD, and apoE4, 9CBC treatment improved long- and short-term memory, decreased neuroinflammation, and reduced the prevalence of β-amyloid plaques and tau hyperphosphorylation. These findings suggest that 9CBC has the potential to be an effective preventive and symptomatic AD therapy.",

keywords = "9-cis beta-carotene, Alzheimer's disease, Beta-carotene, Cognition, Dunaliella, Inflammation",

author = "Rachel Twitto-Greenberg and Sigal Liraz-Zaltsman and Michaelson, {Daniel M.} and Ori Liraz and Irit Lubitz and Dana Atrakchi-Baranes and Chen Shemesh and Uri Ashery and Itzik Cooper and Ayelet Harari and Dror Harats and Michal Schnaider-Beeri and Aviv Shaish",

note = "Publisher Copyright: {\textcopyright} 2023 Elsevier Inc.",

year = "2024",

month = jan,

doi = "10.1016/j.neurobiolaging.2023.09.005",

language = "אנגלית",

volume = "133",

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Twitto-Greenberg, R, Liraz-Zaltsman, S, Michaelson, DM, Liraz, O, Lubitz, I, Atrakchi-Baranes, D, Shemesh, C, Ashery, U, Cooper, I, Harari, A, Harats, D, Schnaider-Beeri, M & Shaish, A 2024, '9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models', Neurobiology of Aging, vol. 133, pp. 16-27. https://doi.org/10.1016/j.neurobiolaging.2023.09.005

9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models. / Twitto-Greenberg, Rachel; Liraz-Zaltsman, Sigal; Michaelson, Daniel M. et al.
In: Neurobiology of Aging, Vol. 133, 01.2024, p. 16-27.

Research output: Contribution to journal › Article › peer-review

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AU - Lubitz, Irit

AU - Atrakchi-Baranes, Dana

AU - Shemesh, Chen

AU - Ashery, Uri

AU - Cooper, Itzik

AU - Harari, Ayelet

AU - Harats, Dror

AU - Schnaider-Beeri, Michal

AU - Shaish, Aviv

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JF - Neurobiology of Aging

ER -

9-cis beta-carotene-enriched diet significantly improved cognition and decreased Alzheimer's disease neuropathology and neuroinflammation in Alzheimer's disease-like mouse models

Abstract

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Keywords

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