A 6-month study of the effects of 0.3% triclosan/copolymer dentifrice on dental implants

Prem K. Sreenivasan, Yuval Vered, Avi Zini, Jonathan Mann, Hilla Kolog, Doron Steinberg, Joseph J. Zambon, Violet I. Haraszthy, Maike P. Da Silva, William De Vizio

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38 Scopus citations


Aim: Supportive therapy to maintain dental implants is increasingly important. This study examined the effect of a 0.3% triclosan/2% copolymer dentifrice on oral biofilms and gingival inflammation (GI) on dental implants and peri-implant tissues. Materials and Methods: One hundred and twenty adults with a dental implant and contra-lateral tooth were enrolled in this 6 month, double-blind, two-treatment, parallel group study. Sixty subjects were randomly assigned to a triclosan/copolymer dentifrice test group and 60 subjects to a fluoride dentifrice control group and instructed to brush twice daily for 6 months. At baseline, 3, and 6 months, a calibrated dentist assessed dental plaque, GI and collected supragingival dental plaque for microbiological analysis. Results: Subjects in the triclosan/copolymer group demonstrated significantly lower levels of dental plaque, gingivitis, and bleeding on probing at 3 and 6 months at both the implant and contra-lateral tooth compared with the fluoride group (p<0.05). There were significantly fewer Gram-negative anaerobes in the triclosan/copolymer group (p<0.05) including >90% reductions in Aggregatibacter actinomycetemcomitans, Campylobacter rectus, Eubacterium saburreum, Fusobacterium nucleatum, Porphyromonas gingivalis, Prevotella melaninogenica, Solobacterium moorei, and Tannerella forsythia. Conclusions: Twice daily use of a triclosan/copolymer dentifrice may enhance dental implant maintenance by reducing dental plaque and GI.

Original languageAmerican English
Pages (from-to)33-42
Number of pages10
JournalJournal of Clinical Periodontology
Issue number1
StatePublished - Jan 2011


  • bacteria
  • biofilm
  • dental implant
  • gingivitis
  • triclosan


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