A bio. tools collection of online resources for GPCR research

Tõnis Laasfeld; Friederike Wunsch; Avgi E. Apostolakou; Adrián García-Recio; Gáspár Pándy-Szekeres; Slawomir Filipek; Masha Y. Niv; Jana Selent; David E. Gloriam; Marcel Bermudez

doi:10.1111/bph.17461

A bio. tools collection of online resources for GPCR research

Tõnis Laasfeld^*, Friederike Wunsch, Avgi E. Apostolakou, Adrián García-Recio, Gáspár Pándy-Szekeres, Slawomir Filipek, Masha Y. Niv, Jana Selent, David E. Gloriam, Marcel Bermudez^*

^*Corresponding author for this work

Institute of Biochemistry, Food Science and Nutrition

Research output: Contribution to journal › Review article › peer-review

Abstract

G protein-coupled receptors are highly complex signal transduction proteins with many potential biomedical applications. Researchers from different fields work together to improve mechanistic understanding of GPCR function and to transfer that knowledge in order to advance therapeutic options. Due to the interdisciplinary nature of GPCR research, many databases and web tools with different types and levels of information are being developed to support scientists in sharing and analysing data. Here, we aim to give an overview of freely available online chemoinformatics and bioinformatics resources specifically designed to aid GPCR research. We compiled a dedicated domain on ELIXIR's bio. tools portal as a continuously updatable repository of GPCR-related online resources (https://bio.tools/t?domain=gpcr). This provides an up-to-date overview of available tools, rather than a static list representing only a snapshot in time. Furthermore, we give some recommendations for developing and using scientific online resources and briefly describe selected databases and web-based tools for GPCR research.

Original language	English
Journal	British Journal of Pharmacology
DOIs	https://doi.org/10.1111/bph.17461
State	Accepted/In press - 2025

Bibliographical note

Publisher Copyright:
© 2025 The Author(s). British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.

Keywords

bioinformatics
databases
drug design
G protein-coupled receptors
web tools

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10.1111/bph.17461

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title = "A bio. tools collection of online resources for GPCR research",

abstract = "G protein-coupled receptors are highly complex signal transduction proteins with many potential biomedical applications. Researchers from different fields work together to improve mechanistic understanding of GPCR function and to transfer that knowledge in order to advance therapeutic options. Due to the interdisciplinary nature of GPCR research, many databases and web tools with different types and levels of information are being developed to support scientists in sharing and analysing data. Here, we aim to give an overview of freely available online chemoinformatics and bioinformatics resources specifically designed to aid GPCR research. We compiled a dedicated domain on ELIXIR's bio. tools portal as a continuously updatable repository of GPCR-related online resources (https://bio.tools/t?domain=gpcr). This provides an up-to-date overview of available tools, rather than a static list representing only a snapshot in time. Furthermore, we give some recommendations for developing and using scientific online resources and briefly describe selected databases and web-based tools for GPCR research.",

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note = "Publisher Copyright: {\textcopyright} 2025 The Author(s). British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society.",

year = "2025",

doi = "10.1111/bph.17461",

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AU - Laasfeld, Tõnis

AU - Wunsch, Friederike

AU - Apostolakou, Avgi E.

AU - García-Recio, Adrián

AU - Pándy-Szekeres, Gáspár

AU - Filipek, Slawomir

AU - Niv, Masha Y.

AU - Selent, Jana

AU - Gloriam, David E.

AU - Bermudez, Marcel

PY - 2025

Y1 - 2025

N2 - G protein-coupled receptors are highly complex signal transduction proteins with many potential biomedical applications. Researchers from different fields work together to improve mechanistic understanding of GPCR function and to transfer that knowledge in order to advance therapeutic options. Due to the interdisciplinary nature of GPCR research, many databases and web tools with different types and levels of information are being developed to support scientists in sharing and analysing data. Here, we aim to give an overview of freely available online chemoinformatics and bioinformatics resources specifically designed to aid GPCR research. We compiled a dedicated domain on ELIXIR's bio. tools portal as a continuously updatable repository of GPCR-related online resources (https://bio.tools/t?domain=gpcr). This provides an up-to-date overview of available tools, rather than a static list representing only a snapshot in time. Furthermore, we give some recommendations for developing and using scientific online resources and briefly describe selected databases and web-based tools for GPCR research.

AB - G protein-coupled receptors are highly complex signal transduction proteins with many potential biomedical applications. Researchers from different fields work together to improve mechanistic understanding of GPCR function and to transfer that knowledge in order to advance therapeutic options. Due to the interdisciplinary nature of GPCR research, many databases and web tools with different types and levels of information are being developed to support scientists in sharing and analysing data. Here, we aim to give an overview of freely available online chemoinformatics and bioinformatics resources specifically designed to aid GPCR research. We compiled a dedicated domain on ELIXIR's bio. tools portal as a continuously updatable repository of GPCR-related online resources (https://bio.tools/t?domain=gpcr). This provides an up-to-date overview of available tools, rather than a static list representing only a snapshot in time. Furthermore, we give some recommendations for developing and using scientific online resources and briefly describe selected databases and web-based tools for GPCR research.

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KW - databases

KW - drug design

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KW - web tools

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A bio. tools collection of online resources for GPCR research

Abstract

Bibliographical note

Keywords

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