A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy

Nissim Benvenisty; Jonathan S. Draper; Paul J. Gokhale; Lyn Healy; Zoe Hewitt; Deborah Hursh; Adam Hodgson; Tenneille E. Ludwig; Nancy Mah; Sarah E. McClelland; Milena Mennecozzi; Florian T. Merkle; Joanne C. Mountford; Martin Pera; Alessandro Prigione; Tristan A. Rodriguez; Andrea Rossi; Foad J. Rouhani; Kourosh Saeb-Parsy; Lucia Selfa Aspiroz; Nika Shakiba; Claudia Spits; Peter D. Tonge; Ivana Barbaric

doi:10.1016/j.stem.2025.03.003

A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy

Nissim Benvenisty
, Jonathan S. Draper
, Paul J. Gokhale
, Lyn Healy
, Zoe Hewitt
, Deborah Hursh
, Adam Hodgson
, Tenneille E. Ludwig
, Nancy Mah
, Sarah E. McClelland
, Milena Mennecozzi
, Florian T. Merkle
, Joanne C. Mountford
, Martin Pera
, Alessandro Prigione
, Tristan A. Rodriguez
, Andrea Rossi
, Foad J. Rouhani
, Kourosh Saeb-Parsy
, Lucia Selfa Aspiroz

Nika Shakiba, Claudia Spits, Peter D. Tonge, Ivana Barbaric^*

^*Corresponding author for this work

Department of Genetics

Research output: Contribution to journal › Comment/debate

4 Scopus citations

Abstract

Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.

Original language	English
Pages (from-to)	508-512
Number of pages	5
Journal	Cell Stem Cell
Volume	32
Issue number	4
DOIs	https://doi.org/10.1016/j.stem.2025.03.003
State	Published - 3 Apr 2025

Bibliographical note

Publisher Copyright:
© 2025 Elsevier Inc.

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.stem.2025.03.003

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Benvenisty, N., Draper, J. S., Gokhale, P. J., Healy, L., Hewitt, Z., Hursh, D., Hodgson, A., Ludwig, T. E., Mah, N., McClelland, S. E., Mennecozzi, M., Merkle, F. T., Mountford, J. C., Pera, M., Prigione, A., Rodriguez, T. A., Rossi, A., Rouhani, F. J., Saeb-Parsy, K., ... Barbaric, I. (2025). A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy. Cell Stem Cell, 32(4), 508-512. https://doi.org/10.1016/j.stem.2025.03.003

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title = "A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy",

abstract = "Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.",

author = "Nissim Benvenisty and Draper, \{Jonathan S.\} and Gokhale, \{Paul J.\} and Lyn Healy and Zoe Hewitt and Deborah Hursh and Adam Hodgson and Ludwig, \{Tenneille E.\} and Nancy Mah and McClelland, \{Sarah E.\} and Milena Mennecozzi and Merkle, \{Florian T.\} and Mountford, \{Joanne C.\} and Martin Pera and Alessandro Prigione and Rodriguez, \{Tristan A.\} and Andrea Rossi and Rouhani, \{Foad J.\} and Kourosh Saeb-Parsy and \{Selfa Aspiroz\}, Lucia and Nika Shakiba and Claudia Spits and Tonge, \{Peter D.\} and Ivana Barbaric",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

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month = apr,

day = "3",

doi = "10.1016/j.stem.2025.03.003",

language = "אנגלית",

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Benvenisty, N, Draper, JS, Gokhale, PJ, Healy, L, Hewitt, Z, Hursh, D, Hodgson, A, Ludwig, TE, Mah, N, McClelland, SE, Mennecozzi, M, Merkle, FT, Mountford, JC, Pera, M, Prigione, A, Rodriguez, TA, Rossi, A, Rouhani, FJ, Saeb-Parsy, K, Selfa Aspiroz, L, Shakiba, N, Spits, C, Tonge, PD & Barbaric, I 2025, 'A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy', Cell Stem Cell, vol. 32, no. 4, pp. 508-512. https://doi.org/10.1016/j.stem.2025.03.003

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AU - Hewitt, Zoe

AU - Hursh, Deborah

AU - Hodgson, Adam

AU - Ludwig, Tenneille E.

AU - Mah, Nancy

AU - McClelland, Sarah E.

AU - Mennecozzi, Milena

AU - Merkle, Florian T.

AU - Mountford, Joanne C.

AU - Pera, Martin

AU - Prigione, Alessandro

AU - Rodriguez, Tristan A.

AU - Rossi, Andrea

AU - Rouhani, Foad J.

AU - Saeb-Parsy, Kourosh

AU - Selfa Aspiroz, Lucia

AU - Shakiba, Nika

AU - Spits, Claudia

AU - Tonge, Peter D.

AU - Barbaric, Ivana

PY - 2025/4/3

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AB - Human pluripotent stem cell (hPSC)-based therapies offer promise but pose potential risks due to culture-acquired genetic variants, some of which have been linked with cancer. An international workshop addressed these concerns, highlighting the need for improved strategies to stratify variants and chart a path toward definitive guidelines in hPSC-based therapy.

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JO - Cell Stem Cell

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ER -

A call to action for deciphering genetic variants in human pluripotent stem cells for cell therapy

Abstract

Bibliographical note

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