A CDE/CHR tandem element regulates cell cycle-dependent repression of cyclin B2 transcription

Christine Lange-zu Dohna, Michael Brandeis, Frieder Berr, Joachim Mössner, Kurt Engeland*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Scopus citations

Abstract

Cyclin B is an important regulator of progression through the cell division cycle. The oscillating appearance of cyclin B1 and B2 proteins during the cell cycle is in part due to fluctuating mRNA levels. We had identified earlier a tandem promoter element named cell cycle-dependent element (CDE) and cell cycle genes homology region (CHR) which regulates cell cycle-dependent transcription of cdc25C, cyclin A and cdc2. Here we describe that cyclin B2 transcription is repressed through a novel CDE/CHR element in resting and G1 cells. By relief of this repression in S and G2 oscillating expression of cyclin B2 mRNA is achieved during the cell cycle. Copyright (C) 2000 Federation of European Biochemical Societies.

Original languageAmerican English
Pages (from-to)77-81
Number of pages5
JournalFEBS Letters
Volume484
Issue number2
DOIs
StatePublished - 3 Nov 2000

Bibliographical note

Funding Information:
We wish to thank Tim Hunt for his generous support during the initial phase of this project. We are indebted to Kristian Helin, Berthold Henglein and Nick Dyson for kindly providing reagents, M. Kamprad and I. Lehmann for their help with the FACS analyses. K.E. is supported by grants from the Bundesministerium für Bildung und Forschung through the IZKF and the Deutsche Forschungsgemeinschaft.

Keywords

  • CDE
  • CHR
  • Cancer
  • Cell cycle
  • E2F
  • Transcriptional repression

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