A chicken homeo box gene with developmentally regulated expression

Abraham Fainsod*, Yosef Gruenbaum

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

Several homeo box sequences were isolated from a chicken (Gallus domesticus) genomic library. One phage, λGG7, was chosen for further study and the single homeo box sequence it contains was characterized. The sequence of the homeo box revealed it to be a distant member of the Antp class of homeo boxes. Expression of the CHox7 gene results in four transcripts, 1.4, 1.9, 2.4 and 3.5 kb in size. Transcript accumulation of the CHox7 gene peaks twice during embryogenesis, once with the 1.4 kb transcript during early somitogenesis and the second time with the 1.9 kb transcript during organogenesis.

Original languageAmerican English
Pages (from-to)381-385
Number of pages5
JournalFEBS Letters
Volume250
Issue number2
DOIs
StatePublished - 3 Jul 1989

Bibliographical note

Funding Information:
Acknowledgements: We wish to thank Dr B.W. O'Malley for the chicken oviduct genomic library, Dr W. McGinnis for the Drosophila probes and Dr F.H. Ruddle for the mouse probes. This work was supported by grants from the United States-Israel Binational Science Foundation (BSF), Jerusalem, Israel (no.86-00014), and the Fund for Basic Research, administered by The Israel Academy of Sciences and Humanities.

Keywords

  • (Antennapedia, Gallus domesticus)
  • Embryogenesis
  • Gene evolution
  • Homeo box

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