A clinical prediction rule and platelet count predict esophageal varices in children

Juan Cristóbal Gana*, Dan Turner, Giorgina Mielivergani, Mark Davenport, Tamir Miloh, Yaron Avitzur, Jason Yap, Veronique Morinville, Herbert Brill, Simon C. Ling

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

66 Scopus citations


Background & Aims: The validation of noninvasive tests to diagnose esophageal varices is a priority in children because repeated endoscopic evaluations are too invasive. We measured the ability of a previously developed noninvasive clinical prediction rule (CPR) to predict the presence of esophageal varices in children. Methods: We analyzed data from 108 children, younger than age 18, who received endoscopies at 8 centers, to assess portal hypertension from chronic liver disease or portal vein obstruction. Blood test and abdominal ultrasound scan results were obtained within 4 months of endoscopy. Grading of varices identified by endoscopy was confirmed by independent blinded review. Spleen size, based on data from the ultrasound scan, was expressed as a standard deviation score relative to normal values for age. Results: Of the children studied, 74 had esophageal varices (69%), including 35 with large varices (32%). The best noninvasive predictors of esophageal varices of any size were as follows: platelet:spleen size z-score ratio (area under the receiver operating characteristic curve [AUROC], 0.84; 95% confidence interval [CI] 0.750.93), CPR (AUROC, 0.80; 95% CI, 0.700.91), and platelet count (AUROC, 0.79; 95% CI, 0.690.90). The positive predictive values for the CPR and platelet count were 0.87 and 0.86, the negative predictive values were 0.64 and 0.63, the positive likelihood ratios were 3.06 and 2.76, and the negative likelihood ratios were 0.64 and 0.63, respectively. Based on positive and negative predictive values, the most accurate noninvasive tests were the CPR and platelet counts. Conclusions: Noninvasive tests such as CPR and platelet count can assist in triaging children for endoscopy to identify esophageal varices.

Original languageAmerican English
Pages (from-to)2009-2016
Number of pages8
Issue number6
StatePublished - Dec 2011


  • Diagnostic Tests
  • Pediatric Chronic Liver Disease
  • Portal Hypertension


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