TY - JOUR
T1 - A combined approach to control valproic acid release via novel delivery system of valpromide
T2 - A kinetic and pharmacokinetic study
AU - Rubinstein, Abraham
AU - Bialer, Meir
AU - Friedman, Michael
AU - Raz, Itamar
AU - Abramsky, Oded
PY - 1986/6
Y1 - 1986/6
N2 - The kinetics of two novel controlled release formulations of valpromide (VPD; designed hereafter as VPDCR1 and VPDCR2) were studied in vitro and were found to follow the Hixson-Crowell cube root law model with a threefold difference between the two valpromide release rate constants. After oral administration of VPDCR1, VPDCR2 and a commercially available standard VPD formulation (Depamide®) to six healthy subjects, valpromide was found to be a prodrug of valproic acid (VPA). Serum levels of valproic acid were monitored, and the pharmacokinetics of VPA and the absorption characteristics of VPDCR1, VPDCR2 and Depamide® were analyzed comparatively. Results from this study suggest that sustained release dosage forms of valpromide have certain advantages over sustained release formulations of valproic acid.
AB - The kinetics of two novel controlled release formulations of valpromide (VPD; designed hereafter as VPDCR1 and VPDCR2) were studied in vitro and were found to follow the Hixson-Crowell cube root law model with a threefold difference between the two valpromide release rate constants. After oral administration of VPDCR1, VPDCR2 and a commercially available standard VPD formulation (Depamide®) to six healthy subjects, valpromide was found to be a prodrug of valproic acid (VPA). Serum levels of valproic acid were monitored, and the pharmacokinetics of VPA and the absorption characteristics of VPDCR1, VPDCR2 and Depamide® were analyzed comparatively. Results from this study suggest that sustained release dosage forms of valpromide have certain advantages over sustained release formulations of valproic acid.
UR - http://www.scopus.com/inward/record.url?scp=0022919305&partnerID=8YFLogxK
U2 - 10.1016/0168-3659(86)90031-3
DO - 10.1016/0168-3659(86)90031-3
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AN - SCOPUS:0022919305
SN - 0168-3659
VL - 4
SP - 33
EP - 38
JO - Journal of Controlled Release
JF - Journal of Controlled Release
IS - 1
ER -