TY - JOUR
T1 - A contribution to our knowledge of coca leaf content substances
AU - Hanus, L.
AU - El-Sohly, M. A.
AU - Turner, C. E.
PY - 1980
Y1 - 1980
N2 - Dried leaves were crushed and extracted in ethanol. The alkaloid fraction was shaken out of the extract. Then it was divided on a silicaged filled column. Partial fractions were purified by further column chromatography and preparative thin-layer chromatography. Identification of single alkaloids was made by comparison with standards on TLG, measurement of IR, UV, NMR and MS spectra and comparison of retention times with standards by gas chromatography. In this way cocaine, trans and cis-methylcinnamoylecgonine, ecgonine methylester, benzoylecgonine, pseudoecgonine methylester, cuscohygrine and mesodihydrocuscohygrine were identified. In the case of meso-di-hydrocuscohygrin, which is a quite new alkaloid isolated from coca leaves, comparison of NMR-spectra after its semisynthetic preparation from a mixture of isolated dl- and meso-cuscohygrine was used for its identification and stereochemical definition.
AB - Dried leaves were crushed and extracted in ethanol. The alkaloid fraction was shaken out of the extract. Then it was divided on a silicaged filled column. Partial fractions were purified by further column chromatography and preparative thin-layer chromatography. Identification of single alkaloids was made by comparison with standards on TLG, measurement of IR, UV, NMR and MS spectra and comparison of retention times with standards by gas chromatography. In this way cocaine, trans and cis-methylcinnamoylecgonine, ecgonine methylester, benzoylecgonine, pseudoecgonine methylester, cuscohygrine and mesodihydrocuscohygrine were identified. In the case of meso-di-hydrocuscohygrin, which is a quite new alkaloid isolated from coca leaves, comparison of NMR-spectra after its semisynthetic preparation from a mixture of isolated dl- and meso-cuscohygrine was used for its identification and stereochemical definition.
UR - http://www.scopus.com/inward/record.url?scp=0019198053&partnerID=8YFLogxK
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
AN - SCOPUS:0019198053
SN - 0001-7604
VL - 22
SP - 220
EP - 221
JO - Activitas Nervosa Superior
JF - Activitas Nervosa Superior
IS - 3
ER -