A familial Alzheimer's disease locus on chromosome I

Ephrat Levy-Lahad; Ellen M. Wijsman; Ellen Nemens; Leojean Anderson; Katrina A.B. Goddard; James L. Weber; Thomas D. Bird; Gerard D. Schellenberg

doi:10.1126/science.7638621

A familial Alzheimer's disease locus on chromosome I

Ephrat Levy-Lahad
, Ellen M. Wijsman
, Ellen Nemens
, Leojean Anderson
, Katrina A.B. Goddard
, James L. Weber
, Thomas D. Bird
, Gerard D. Schellenberg^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

734 Scopus citations

Abstract

The Volga German kindreds are a group of seven related families with autosomal dominant early-onset Alzheimer's disease (AD). Linkage to known AD-related loci on chromosomes 21 and 14 has been excluded. Significant evidence for linkage to AD in these families was obtained with D1S479 and there was also positive evidence for linkage with other markers in the region. A 112-base pair allele of D1S479 co-segregated with the disease in five of seven families, which is consistent with a common genetic founder. This study demonstrates the presence of an AD locus on chromosome 1q31-42.

Original language	English
Pages (from-to)	970-973
Number of pages	4
Journal	Science
Volume	269
Issue number	5226
DOIs	https://doi.org/10.1126/science.7638621
State	Published - 1995
Externally published	Yes

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title = "A familial Alzheimer's disease locus on chromosome I",

abstract = "The Volga German kindreds are a group of seven related families with autosomal dominant early-onset Alzheimer's disease (AD). Linkage to known AD-related loci on chromosomes 21 and 14 has been excluded. Significant evidence for linkage to AD in these families was obtained with D1S479 and there was also positive evidence for linkage with other markers in the region. A 112-base pair allele of D1S479 co-segregated with the disease in five of seven families, which is consistent with a common genetic founder. This study demonstrates the presence of an AD locus on chromosome 1q31-42.",

author = "Ephrat Levy-Lahad and Wijsman, \{Ellen M.\} and Ellen Nemens and Leojean Anderson and Goddard, \{Katrina A.B.\} and Weber, \{James L.\} and Bird, \{Thomas D.\} and Schellenberg, \{Gerard D.\}",

year = "1995",

doi = "10.1126/science.7638621",

language = "אנגלית",

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pages = "970--973",

journal = "Science",

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publisher = "American Association for the Advancement of Science",

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T1 - A familial Alzheimer's disease locus on chromosome I

AU - Levy-Lahad, Ephrat

AU - Wijsman, Ellen M.

AU - Nemens, Ellen

AU - Anderson, Leojean

AU - Goddard, Katrina A.B.

AU - Weber, James L.

AU - Bird, Thomas D.

AU - Schellenberg, Gerard D.

PY - 1995

Y1 - 1995

N2 - The Volga German kindreds are a group of seven related families with autosomal dominant early-onset Alzheimer's disease (AD). Linkage to known AD-related loci on chromosomes 21 and 14 has been excluded. Significant evidence for linkage to AD in these families was obtained with D1S479 and there was also positive evidence for linkage with other markers in the region. A 112-base pair allele of D1S479 co-segregated with the disease in five of seven families, which is consistent with a common genetic founder. This study demonstrates the presence of an AD locus on chromosome 1q31-42.

AB - The Volga German kindreds are a group of seven related families with autosomal dominant early-onset Alzheimer's disease (AD). Linkage to known AD-related loci on chromosomes 21 and 14 has been excluded. Significant evidence for linkage to AD in these families was obtained with D1S479 and there was also positive evidence for linkage with other markers in the region. A 112-base pair allele of D1S479 co-segregated with the disease in five of seven families, which is consistent with a common genetic founder. This study demonstrates the presence of an AD locus on chromosome 1q31-42.

UR - https://www.scopus.com/pages/publications/0029150716

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SN - 0036-8075

VL - 269

SP - 970

EP - 973

JO - Science

JF - Science

IS - 5226

ER -

A familial Alzheimer's disease locus on chromosome I

Abstract

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