A high molecular mass cranberry constituent reduces mutans streptococci level in saliva and inhibits in vitro adhesion to hydroxyapatite

Ervin I. Weiss; Avital Kozlovsky; Doron Steinberg; Ron Lev-Dor; Ronit Bar Ness Greenstein; Mark Feldman; Nathan Sharon; Itzhak Ofek

doi:10.1016/S0378-1097(04)00035-7

A high molecular mass cranberry constituent reduces mutans streptococci level in saliva and inhibits in vitro adhesion to hydroxyapatite

Ervin I. Weiss^*, Avital Kozlovsky, Doron Steinberg, Ron Lev-Dor, Ronit Bar Ness Greenstein, Mark Feldman, Nathan Sharon, Itzhak Ofek

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

101 Scopus citations

Abstract

Previous investigations showed that a high molecular mass, non-dialyzable material (NDM) from cranberries inhibits the adhesion of a number of bacterial species and prevents the co-aggregation of many oral bacterial pairs. In the present study we determined the effect of mouthwash supplemented with NDM on oral hygiene. Following 6 weeks of daily usage of cranberry-containing mouthwash by an experimental group (n=29), we found that salivary mutans streptococci count as well as the total bacterial count were reduced significantly (ANOVA, P<0.01) compared with those of the control (n=30) using placebo mouthwash. No change in the plaque and gingival indices was observed. In vitro, the cranberry constituent inhibited the adhesion of Streptococcus sobrinus to saliva-coated hydroxyapatite. The data suggest that the ability to reduce mutans streptococci counts in vivo is due to the anti-adhesion activity of the cranberry constituent.

Original language	English
Pages (from-to)	89-92
Number of pages	4
Journal	FEMS Microbiology Letters
Volume	232
Issue number	1
DOIs	https://doi.org/10.1016/S0378-1097(04)00035-7
State	Published - 12 Mar 2004
Externally published	Yes

Bibliographical note

Funding Information:
This study was performed in part at the R. Goldstein Research Center, Faculty of Dentistry, Hebrew University-Hadassah, and at the Alpha Omega Research Laboratories, School of Dental Medicine, Tel Aviv University. The work was supported in part by a grant from Ocean Spray, Inc.

Keywords

Anti-adhesion
Antibacterial
Cranberry
Hydroxyapatite
Mouthwash
Mutans streptococcus
Saliva

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10.1016/S0378-1097(04)00035-7

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title = "A high molecular mass cranberry constituent reduces mutans streptococci level in saliva and inhibits in vitro adhesion to hydroxyapatite",

abstract = "Previous investigations showed that a high molecular mass, non-dialyzable material (NDM) from cranberries inhibits the adhesion of a number of bacterial species and prevents the co-aggregation of many oral bacterial pairs. In the present study we determined the effect of mouthwash supplemented with NDM on oral hygiene. Following 6 weeks of daily usage of cranberry-containing mouthwash by an experimental group (n=29), we found that salivary mutans streptococci count as well as the total bacterial count were reduced significantly (ANOVA, P<0.01) compared with those of the control (n=30) using placebo mouthwash. No change in the plaque and gingival indices was observed. In vitro, the cranberry constituent inhibited the adhesion of Streptococcus sobrinus to saliva-coated hydroxyapatite. The data suggest that the ability to reduce mutans streptococci counts in vivo is due to the anti-adhesion activity of the cranberry constituent.",

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note = "Funding Information: This study was performed in part at the R. Goldstein Research Center, Faculty of Dentistry, Hebrew University-Hadassah, and at the Alpha Omega Research Laboratories, School of Dental Medicine, Tel Aviv University. The work was supported in part by a grant from Ocean Spray, Inc.",

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AU - Greenstein, Ronit Bar Ness

AU - Feldman, Mark

AU - Sharon, Nathan

AU - Ofek, Itzhak

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A high molecular mass cranberry constituent reduces mutans streptococci level in saliva and inhibits in vitro adhesion to hydroxyapatite

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