A high-performance electrochemical sensor based on g-C3N4-E-PEDOT for the determination of acetaminophen

Yujuan Xu, Wu Lei, Juan Su, Jinjin Hu, Xiaodan Yu, Tong Zhou, Yun Yang, Daniel Mandler, Qingli Hao*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

71 Scopus citations

Abstract

A fast, ultrasensitive electrochemical sensing platform based on graphitic carbon nitride-electrochemically deposited-poly(3,4-ethylenedioxythiophene) (g-C3N4-E-PEDOT) composite was constructed by in-situ electropolymerization and applied for the quantitative determination of acetaminophen (AP). E-PEDOT was introduced as the conducting matrix for developing g-C3N4 composite to complement the poor conductivity disadvantage of g-C3N4. The strong affinity and synergetic effect between g-C3N4 and E-PEDOT, which were analyzed by PM6 computational calculation, highly improved the electron transfer property and remarkably enhanced the electrochemical catalytic activity of the composite. The g-C3N4-E-PEDOT modified glassy carbon electrode (GCE) demonstrated better electrocatalytic activity towards the oxidation of AP than bare, g-C3N4 and E-PEDOT modified ones. Under the optimized conditions, the oxidation peak currents at the g-C3N4-E-PEDOT/GCE increased linearly in the concentration range of AP from 0.01 to 2 μM and 2–100 μM, and an ultra-low limit of detection (LOD) of 34.28 nM was obtained (S/N = 3). In addition, the g-C3N4-E-PEDOT/GCE was successfully applied for the AP determination in the clinical human serum, and also exhibited excellent selectivity, reproducibility and stability. Except the novel AP determination approach, moreover, this work provided a new electrochemical application angle of graphitic carbon nitride theoretically as well as experimentally.

Original languageAmerican English
Pages (from-to)994-1003
Number of pages10
JournalElectrochimica Acta
Volume259
DOIs
StatePublished - 1 Jan 2018

Bibliographical note

Publisher Copyright:
© 2017 Elsevier Ltd

Keywords

  • Acetaminophen
  • Electrochemical sensors
  • Graphitic carbon nitride
  • PEDOT

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