A high-resolution single nucleotide polymorphism genetic map of the mouse genome

Sagiv Shifman, Jordana Tzenova Bell, Richard R. Copley, Martin S. Taylor, Robert W. Williams, Richard Mott, Jonathan Flint*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

218 Scopus citations

Abstract

High-resolution genetic maps are required for mapping complex traits and for the study of recombination. We report the highest density genetic map yet created for any organism, except humans. Using more than 10,000 single nucleotide polymorphisms evenly spaced across the mouse genome, we have constructed genetic maps for both outbred and inbred mice, and separately for males and females. Recombination rates are highly correlated in outbred and inbred mice, but show relatively low correlation between males and females. Differences between male and female recombination maps and the sequence features associated with recombination are strikingly similar to those observed in humans. Genetic maps are available from http://gscan.well.ox.ac.uk/#genetic_map and as supporting information to this publication.

Original languageAmerican English
Pages (from-to)2227-2237
Number of pages11
JournalPLoS Biology
Volume4
Issue number12
DOIs
StatePublished - Dec 2006
Externally publishedYes

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