A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli

Ilana Kolodkin-Gal; Ronen Hazan; Ariel Gaathon; Shmuel Carmeli; Hanna Engelberg-Kulka

doi:10.1126/science.1147248

A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli

Ilana Kolodkin-Gal
, Ronen Hazan
, Ariel Gaathon
, Shmuel Carmeli
, Hanna Engelberg-Kulka^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

219 Scopus citations

Abstract

mazEF is a toxin-antitoxin module located on many bacterial chromosomes, including those of pathogens. Here, we report that Escherichia coli mazEF-mediated cell death is a population phenomenon requiring a quorum-sensing molecule that we call the extracellular death factor (EDF). Structural analysis revealed that EDF is a linear pentapeptide, Asn-Asn-Trp-Asn-Asn. Each of the five amino acids of EDF is important for its activity.

Original language	English
Pages (from-to)	652-655
Number of pages	4
Journal	Science
Volume	318
Issue number	5850
DOIs	https://doi.org/10.1126/science.1147248
State	Published - 26 Oct 2007

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AU - Carmeli, Shmuel

AU - Engelberg-Kulka, Hanna

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AB - mazEF is a toxin-antitoxin module located on many bacterial chromosomes, including those of pathogens. Here, we report that Escherichia coli mazEF-mediated cell death is a population phenomenon requiring a quorum-sensing molecule that we call the extracellular death factor (EDF). Structural analysis revealed that EDF is a linear pentapeptide, Asn-Asn-Trp-Asn-Asn. Each of the five amino acids of EDF is important for its activity.

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A linear pentapeptide is a quorum-sensing factor required for mazEF-mediated cell death in Escherichia coli

Abstract

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