A lipid-and-polymer-based novel local drug delivery system - BonyPid : From physicochemical aspects to therapy of bacterially infected bones

Noam Emanuel*, Yosef Rosenfeld, Or Cohen, Yaakov H. Applbaum, David Segal, Yechezkel Barenholz

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Bacterial infection of bone may result in bone destruction and is difficult to cure due to poor accessibility to bone of systemically-administrated antibiotic and poor performance of currently available local antibacterial treatments. We developed a novel local drug delivery system based on self-assembly of specific familiar lipids and polymers that encapsulate the desired drug (exemplified by doxycycline). The entrapped doxycycline present in the anhydrous environment of the formulation is fully protected from long-term water-exposure-related degradation. The fine coating of the tricalcium phosphate bone filler by this doxycycline-containing formulation (BonyPid™) is capable of releasing intact and active drug at a steady, zero-order rate for a predetermined period of up to 30 days and in amount sufficient to achieve therapy potentially capable of eliminating the contaminating bacteria. Therefore a clinical evaluation is proposed for testing the efficacy and toxicity of BonyPid for therapy of bacterial bone infections.

Original languageEnglish
Pages (from-to)353-361
Number of pages9
JournalJournal of Controlled Release
Volume160
Issue number2
DOIs
StatePublished - 10 Jun 2012

Keywords

  • Antibiotic
  • Bone filler
  • Bone infection
  • BonyPid
  • Zero-order kinetics

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