Salivary gland dysfunction is a common sequela of the bone marrow transplantation procedure. We determined the effect of different bone marrow transplantation protocols on parotid salivary flow rate. Salivary secretion was substantially reduced during conditioning of all the recipients. A gradual flow rate reconstitution could be detected as soon as a few days after the bone marrow transplantation. Eight patients conditioned with total lymph node irradiation and chemotherapy or chemotherapy alone displayed earlier and complete recovery of saliva secretions 2 to 5 months after the grafting. Recovery was delayed and incomplete when total body irradiation was added to the conditioning regimen (seven patients). Six of these patients also developed graft-versus-host disease. The results suggest that total body irradiation induces irreversible damage to the parotid glands resulting in profound xerostomia followed by opportunistic infections. Chemotherapy with or without total lymph node irradiation does not induce such damage.
|Original language||American English|
|Number of pages||6|
|Journal||Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology|
|State||Published - Feb 1995|
Bibliographical noteFunding Information:
Supported by Concern Foundation II, the Society of Research Associates of the Lautenberg Center and Israel Cancer Research Fund. aLautenberg Center of General and Tumor Immunology and Oral Medicine Services. bAssociate Professor, Lautenberg Center of General and Tumor Immunology. eProfessor and Chairman, Department of Bone Marrow Transplantation. dSenior Lecturer, Department of Bone Marrow Transplantation. eProfessor and Chairman, Oral Medicine Service. Copyright | 1995 by Mosby-Year Book, Inc. 1079-2104/95/$3.00 + 0 7/13/60603