A low molecular weight copper chelator crosses the blood-brain barrier and attenuates experimental autoimmune encephalomyelitis

Keyphrases

• Low Molecular Weight 100%
• Blood-brain Barrier 100%
• Multiple Sclerosis 100%
• Mitogen-activated Protein Kinase 100%
• Experimental Autoimmune Encephalomyelitis 100%
• Copper Chelator 100%
• Matrix metalloproteinase-9 (MMP-9) 66%
• Myelin Oligodendrocyte Glycoprotein 66%
• C-Jun N-terminal Protein Kinase 66%
• Clinical Signs 33%
• Inflammation 33%
• Mouse Model 33%
• Neurodegenerative Diseases 33%
• Axon 33%
• Oral Administration 33%
• Reactive Oxygen Species Production 33%
• Chelates 33%
• Cu2+ 33%
• Reactive Oxygen Species 33%
• Etiology 33%
• Inflammatory Response 33%
• In Vitro Study 33%
• Protein Matrix 33%
• Low Toxicity 33%
• Matrix Metalloproteinases 33%
• Enhanced Production 33%
• Free Radical Formation 33%
• Induced Activation 33%
• Reactive Oxygen Species Scavenging 33%
• Activated Pathways 33%
• MAPK p38 33%
• Pathological Damage 33%
• Phosphorylated Intermediate 33%
• N-acetylcysteine Amide 33%
• Blood-brain Barrier Penetration 33%

Neuroscience

• Reactive Oxygen Species 100%
• Blood Brain Barrier 100%
• Chelating Agent 100%
• Mitogen-Activated Protein Kinase 100%
• Experimental Autoimmune Encephalomyelitis 100%
• Amino Terminal Sequence 66%
• Multiple Sclerosis 66%
• MMP9 66%
• Protein Kinases 66%
• Myelin Oligodendrocyte Glycoprotein 66%
• In Vitro 33%
• Neurodegenerative Disorder 33%
• Matrix Metalloproteinase 33%
• Acetylcysteine 33%
• Protein Kinase C 33%
• Carboxamide 33%
• Free Radical 33%
• P38 Mitogen-Activated Protein Kinases 33%
• Axon 33%
• Etiology of Multiple Sclerosis 33%

Pharmacology, Toxicology and Pharmaceutical Science

• Reactive Oxygen Metabolite 100%
• Chelating Agent 100%
• Experimental Autoimmune Encephalomyelitis 100%
• Multiple Sclerosis 100%
• Blood-Brain Barrier 100%
• Inflammation 66%
• Gelatinase B 66%
• Protein Kinases 66%
• Mitogen Activated Protein Kinase 66%
• Mouse Model 33%
• Carboxamide 33%
• Matrix Metalloproteinase 33%
• Free Radical 33%
• Protein Kinase C 33%
• Cuprous Ion 33%
• Myelin Oligodendrocyte Glycoprotein 33%
• MOG-induced Experimental Autoimmune Encephalomyelitis 33%
• N-Acetylcysteine 33%
• Oral Administration 33%