A marked synergistic effect in antitumor activity of salan titanium(IV) complexes bearing two differently substituted aromatic rings

Hagai Glasner, Edit Y. Tshuva*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

51 Scopus citations

Abstract

Salan titanium(IV) complexes of differently substituted aromatic rings, where one ring is para-nitrated and another is ortho,para-halogenated, demonstrate exceptionally high anticancer activity, with IC 50 values of <1 μM, exceeding that of cisplatin by ∼30-fold. Whereas an additive effect in hydrolytic stability was detected for these highly stable complexes, an unexpected synergistic effect in anticancer activity makes these hybrid complexes substantially more active than both their symmetrical analogues alone and their equimolar mixture.

Original languageAmerican English
Pages (from-to)16812-16814
Number of pages3
JournalJournal of the American Chemical Society
Volume133
Issue number42
DOIs
StatePublished - 26 Oct 2011

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