TY - JOUR
T1 - A mathematical morel for drug release from 0/w emulsions
T2 - Application to controlled release morphine emulsions
AU - Friedman, D.
AU - Benita, S.
PY - 1987
Y1 - 1987
N2 - Stable morphine submicronized emulsions were prepared under optimal experimental conditions. Mean droplet size and zeta potential of the morphine emulsions ranged from 400 to 700 nm and from -50 to -70 mv respectively. In vitro release kinetic analysis indicated that the drug transfer from the oily dispersed droplets into the external aqueous phase was the rate determining step in the overall kinetic process providing the main portion of the drug 'twas localized in the oily phase. A kinetic equation model was proposed and found suitable for the description of morphine release from the emulsion due to conformity of the experimental data to the expected kinetic data as calculated by means of this equation.
AB - Stable morphine submicronized emulsions were prepared under optimal experimental conditions. Mean droplet size and zeta potential of the morphine emulsions ranged from 400 to 700 nm and from -50 to -70 mv respectively. In vitro release kinetic analysis indicated that the drug transfer from the oily dispersed droplets into the external aqueous phase was the rate determining step in the overall kinetic process providing the main portion of the drug 'twas localized in the oily phase. A kinetic equation model was proposed and found suitable for the description of morphine release from the emulsion due to conformity of the experimental data to the expected kinetic data as calculated by means of this equation.
UR - http://www.scopus.com/inward/record.url?scp=0000293248&partnerID=8YFLogxK
U2 - 10.3109/03639048709068707
DO - 10.3109/03639048709068707
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AN - SCOPUS:0000293248
SN - 0363-9045
VL - 13
SP - 2067
EP - 2085
JO - Drug Development and Industrial Pharmacy
JF - Drug Development and Industrial Pharmacy
IS - 9-11
ER -