A mimic of superoxide dismutase activity protects Chlorella sorokiniana against the toxicity of sulfite

Haim D. Rabinowitch, Gerald M. Rosen, Irwin Fridovich*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

The spin-trapping agent 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) has been used to demonstrate the light-dependent production of O2 - by Chlorella sorokiniana. In the presence of SO3 = a light-dependent production of the sulfur trioxy anion radical (SO3 -.) could also be seen. A complex prepared by reacting desferrioxamine with MnO2, which catalyzes the dismutation of O2 -, protected the alga against the toxicity of sulfite. The data suggest that SO2 toxicity is at least partially due to the effects of sulfoxy-free radicals generated by the oxidation of SO3 = by O2 -.

Original languageEnglish
Pages (from-to)45-48
Number of pages4
JournalFree Radical Biology and Medicine
Volume6
Issue number1
DOIs
StatePublished - 1989

Fingerprint

Dive into the research topics of 'A mimic of superoxide dismutase activity protects Chlorella sorokiniana against the toxicity of sulfite'. Together they form a unique fingerprint.

Cite this