A mimic of superoxide dismutase activity protects Chlorella sorokiniana against the toxicity of sulfite

Haim D. Rabinowitch; Gerald M. Rosen; Irwin Fridovich

doi:10.1016/0891-5849(89)90158-5

A mimic of superoxide dismutase activity protects Chlorella sorokiniana against the toxicity of sulfite

Haim D. Rabinowitch
, Gerald M. Rosen
, Irwin Fridovich^*

^*Corresponding author for this work

Institute of Plant Sciences and Genetics in Agriculture

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The spin-trapping agent 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) has been used to demonstrate the light-dependent production of O₂ ^- by Chlorella sorokiniana. In the presence of SO₃ ⁼ a light-dependent production of the sulfur trioxy anion radical (SO₃ ^-.) could also be seen. A complex prepared by reacting desferrioxamine with MnO₂, which catalyzes the dismutation of O₂ ^-, protected the alga against the toxicity of sulfite. The data suggest that SO₂ toxicity is at least partially due to the effects of sulfoxy-free radicals generated by the oxidation of SO₃ ⁼ by O₂ ^-.

Original language	English
Pages (from-to)	45-48
Number of pages	4
Journal	Free Radical Biology and Medicine
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/0891-5849(89)90158-5
State	Published - 1989

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title = "A mimic of superoxide dismutase activity protects Chlorella sorokiniana against the toxicity of sulfite",

abstract = "The spin-trapping agent 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) has been used to demonstrate the light-dependent production of O2 - by Chlorella sorokiniana. In the presence of SO3 = a light-dependent production of the sulfur trioxy anion radical (SO3 -.) could also be seen. A complex prepared by reacting desferrioxamine with MnO2, which catalyzes the dismutation of O2 -, protected the alga against the toxicity of sulfite. The data suggest that SO2 toxicity is at least partially due to the effects of sulfoxy-free radicals generated by the oxidation of SO3 = by O2 -.",

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AU - Rosen, Gerald M.

AU - Fridovich, Irwin

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N2 - The spin-trapping agent 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) has been used to demonstrate the light-dependent production of O2 - by Chlorella sorokiniana. In the presence of SO3 = a light-dependent production of the sulfur trioxy anion radical (SO3 -.) could also be seen. A complex prepared by reacting desferrioxamine with MnO2, which catalyzes the dismutation of O2 -, protected the alga against the toxicity of sulfite. The data suggest that SO2 toxicity is at least partially due to the effects of sulfoxy-free radicals generated by the oxidation of SO3 = by O2 -.

AB - The spin-trapping agent 5,5-dimethyl-1-pyrroline-N-oxide (DMPO) has been used to demonstrate the light-dependent production of O2 - by Chlorella sorokiniana. In the presence of SO3 = a light-dependent production of the sulfur trioxy anion radical (SO3 -.) could also be seen. A complex prepared by reacting desferrioxamine with MnO2, which catalyzes the dismutation of O2 -, protected the alga against the toxicity of sulfite. The data suggest that SO2 toxicity is at least partially due to the effects of sulfoxy-free radicals generated by the oxidation of SO3 = by O2 -.

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A mimic of superoxide dismutase activity protects Chlorella sorokiniana against the toxicity of sulfite

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