TY - JOUR
T1 - A model for proto-tRNA loading
AU - Yusim, Karina
AU - Nir, Shlomo
AU - Lahav, Noam
PY - 2001/1/7
Y1 - 2001/1/7
N2 - A kinetic model for loading of proto-tRNA is presented. The kinetic parameters were first estimated from the results of Francklyn & Schimmel (1989; Nature 337, 478-481), who studied the aminoacylation of both tRNA and its minihelix. Then these parameters were reduced several-fold, as is more appropriate for the prebiotic world. The simulations revealed a very slow time course of the loading reaction. We also consider a possibility for the proto-tRNA loading without a catalyst and discuss the feasibility of such processes. Analytical approximations are presented for the kinetics of proto-tRNA loading with and without enzyme. An estimate is given for the time required for the development of template- and sequence-directed systems.
AB - A kinetic model for loading of proto-tRNA is presented. The kinetic parameters were first estimated from the results of Francklyn & Schimmel (1989; Nature 337, 478-481), who studied the aminoacylation of both tRNA and its minihelix. Then these parameters were reduced several-fold, as is more appropriate for the prebiotic world. The simulations revealed a very slow time course of the loading reaction. We also consider a possibility for the proto-tRNA loading without a catalyst and discuss the feasibility of such processes. Analytical approximations are presented for the kinetics of proto-tRNA loading with and without enzyme. An estimate is given for the time required for the development of template- and sequence-directed systems.
UR - http://www.scopus.com/inward/record.url?scp=0035819419&partnerID=8YFLogxK
U2 - 10.1006/jtbi.2000.2204
DO - 10.1006/jtbi.2000.2204
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C2 - 11162056
AN - SCOPUS:0035819419
SN - 0022-5193
VL - 208
SP - 109
EP - 116
JO - Journal of Theoretical Biology
JF - Journal of Theoretical Biology
IS - 1
ER -