A molecular view on pluripotent stem cells

Rachel Eiges, Nissim Benvenisty*

*Corresponding author for this work

Research output: Contribution to journalShort surveypeer-review

36 Scopus citations

Abstract

Pluripotent stem cells are undifferentiated cells that are capable of differentiating to all three embryonic germ layers and their differentiated derivatives. They are transiently found during embryogenesis, in preimplantation embryos and fetal gonads, or as established cell lines. These unique cell types are distinguished by their wide developmental potential and by their ability to be propagated in culture indefinitely, without loosing their undifferentiated phenotype. This short review intends to give a general overview on the pluripotent nature of embryo-derived stem cells with a focus on human embryonic stem cells.

Original languageAmerican English
Pages (from-to)135-141
Number of pages7
JournalFEBS Letters
Volume529
Issue number1
DOIs
StatePublished - 2 Oct 2002

Bibliographical note

Funding Information:
This study was partially supported by the Juvenile Diabetes Foundation, by Curis Inc. and by the Herbert Cohn Chair (N.B.).

Keywords

  • Embryoid body
  • Embryonic stem cell
  • Germ cell
  • Pluripotency
  • Self-renewal
  • Teratoma

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