A mortalization theory for the control of cell proliferation and for the origin of immortal cell lines

Sydney Shall; Wilfred D. Stein

doi:10.1016/0022-5193(79)90371-0

A mortalization theory for the control of cell proliferation and for the origin of immortal cell lines

Sydney Shall^*, Wilfred D. Stein

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

An increasing rate of cellular mortalization sets a limit to the proliferation of fibroblast populations. Failure of the mortalization mechanism leads to the formation of immortal clones of cells. A possible molecular model for the mortalization process is described.

Original language	English
Pages (from-to)	219-231
Number of pages	13
Journal	Journal of Theoretical Biology
Volume	76
Issue number	2
DOIs	https://doi.org/10.1016/0022-5193(79)90371-0
State	Published - 21 Jan 1979
Externally published	Yes

Access to Document

10.1016/0022-5193(79)90371-0

Cite this

@article{60cff297f1bd4adcbf33eead222b0cf9,

title = "A mortalization theory for the control of cell proliferation and for the origin of immortal cell lines",

abstract = "An increasing rate of cellular mortalization sets a limit to the proliferation of fibroblast populations. Failure of the mortalization mechanism leads to the formation of immortal clones of cells. A possible molecular model for the mortalization process is described.",

author = "Sydney Shall and Stein, \{Wilfred D.\}",

year = "1979",

month = jan,

day = "21",

doi = "10.1016/0022-5193(79)90371-0",

language = "אנגלית",

volume = "76",

pages = "219--231",

journal = "Journal of Theoretical Biology",

issn = "0022-5193",

publisher = "Academic Press",

number = "2",

}

TY - JOUR

T1 - A mortalization theory for the control of cell proliferation and for the origin of immortal cell lines

AU - Shall, Sydney

AU - Stein, Wilfred D.

PY - 1979/1/21

Y1 - 1979/1/21

N2 - An increasing rate of cellular mortalization sets a limit to the proliferation of fibroblast populations. Failure of the mortalization mechanism leads to the formation of immortal clones of cells. A possible molecular model for the mortalization process is described.

AB - An increasing rate of cellular mortalization sets a limit to the proliferation of fibroblast populations. Failure of the mortalization mechanism leads to the formation of immortal clones of cells. A possible molecular model for the mortalization process is described.

UR - http://www.scopus.com/inward/record.url?scp=0018377134&partnerID=8YFLogxK

U2 - 10.1016/0022-5193(79)90371-0

DO - 10.1016/0022-5193(79)90371-0

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 431096

AN - SCOPUS:0018377134

SN - 0022-5193

VL - 76

SP - 219

EP - 231

JO - Journal of Theoretical Biology

JF - Journal of Theoretical Biology

IS - 2

ER -

A mortalization theory for the control of cell proliferation and for the origin of immortal cell lines

Abstract

Access to Document

Other files and links

Fingerprint

Cite this