A mortalization theory for the control of cell proliferation and for the origin of immortal cell lines

Sydney Shall; Wilfred D. Stein

doi:10.1016/0022-5193(79)90371-0

A mortalization theory for the control of cell proliferation and for the origin of immortal cell lines

Sydney Shall^*
, Wilfred D. Stein

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

34 Scopus citations

Abstract

An increasing rate of cellular mortalization sets a limit to the proliferation of fibroblast populations. Failure of the mortalization mechanism leads to the formation of immortal clones of cells. A possible molecular model for the mortalization process is described.

Original language	English
Pages (from-to)	219-231
Number of pages	13
Journal	Journal of Theoretical Biology
Volume	76
Issue number	2
DOIs	https://doi.org/10.1016/0022-5193(79)90371-0
State	Published - 21 Jan 1979
Externally published	Yes

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10.1016/0022-5193(79)90371-0

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title = "A mortalization theory for the control of cell proliferation and for the origin of immortal cell lines",

abstract = "An increasing rate of cellular mortalization sets a limit to the proliferation of fibroblast populations. Failure of the mortalization mechanism leads to the formation of immortal clones of cells. A possible molecular model for the mortalization process is described.",

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A mortalization theory for the control of cell proliferation and for the origin of immortal cell lines

Abstract

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