“A narrow bridge home”: The dorsal mesentery in primordial germ cell migration

Gideon Hen, Dalit Sela-Donenfeld*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

8 Scopus citations


Specification of primordial germ cells (PGCs) in all vertebrates takes place in extragonadal sites. This requires migration of PGCs through embryonic tissues towards the genital ridges by both passive and active types of migration. Commonly, colonization in the genital ridges follows migration of the PGCs along the thin tissue of the dorsal mesentery. Here we review the anatomy of the dorsal mesentery, the role it plays in migration of PGCs, and the interactions of PGCs with different cell types, extracellular matrix and signaling pathways that are all essential for attraction and orientation of PGCs along the dorsal mesentery towards the gonad anlage.

Original languageAmerican English
Pages (from-to)97-104
Number of pages8
JournalSeminars in Cell and Developmental Biology
StatePublished - Aug 2019

Bibliographical note

Publisher Copyright:
© 2018 Elsevier Ltd


  • Cell migration
  • Chick embryo
  • Dorsal mesentery
  • Embryo
  • Epiblast
  • Genital ridge
  • Gonad
  • Gut tilting
  • Left-right asymmetry
  • Neural crest cells
  • Primordial germ cells


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