A neural circuit for spatial orientation derived from brain lesions

Moshe Roseman*, Uri Elias, Isaiah Kletenik, Michael A. Ferguson, Michael D. Fox, Zalman Horowitz, Gad A. Marshall, Hugo J. Spiers, Shahar Arzy

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


There is disagreement regarding the major components of the brain network supporting spatial cognition. To address this issue, we applied a lesion mapping approach to the clinical phenomenon of topographical disorientation. Topographical disorientation is the inability to maintain accurate knowledge about the physical environment and use it for navigation. A review of published topographical disorientation cases identified 65 different lesion sites. Our lesion mapping analysis yielded a topographical disorientation brain map encompassing the classic regions of the navigation network: medial parietal, medial temporal, and temporo-parietal cortices. We also identified a ventromedial region of the prefrontal cortex, which has been absent from prior descriptions of this network. Moreover, we revealed that the regions mapped are correlated with the Default Mode Network sub-network C. Taken together, this study provides causal evidence for the distribution of the spatial cognitive system, demarking the major components and identifying novel regions.

Original languageAmerican English
Article numberbhad486
JournalCerebral Cortex
Issue number1
StatePublished - 14 Jan 2024

Bibliographical note

Publisher Copyright:
© 2023 The Author(s). Published by Oxford University Press. All rights reserved.


  • connectivity
  • disorientation
  • navigation
  • network
  • space


Dive into the research topics of 'A neural circuit for spatial orientation derived from brain lesions'. Together they form a unique fingerprint.

Cite this