Abstract
(Figure Presented) Breaking the habit. A new mechanism, called reversed dual hydrogen abstraction (R-DHA), is presented for ethanol oxidation by cytochrome P450 2E1 (CYP2E1). It is shown that the competition of R-DHA with the consensus mechanism (gem-diol) is modulated by the ethanol population in the enzyme pocket. Thus, as a response to growing blood ethanol level, CYP2E1 adapts its ethanol metabolism by a mechanistic switch from gem-diol to R-DHA.
Original language | English |
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Pages (from-to) | 277-281 |
Number of pages | 5 |
Journal | ChemBioChem |
Volume | 8 |
Issue number | 3 |
DOIs | |
State | Published - 12 Feb 2007 |
Keywords
- Cytochrome P450
- Density functional calculations
- Enzyme catalysis
- Heme proteins
- Oxygenation