TY - JOUR
T1 - A New Route of Drug Administration
T2 - Intrauterine Delivery of Insulin and Calcitonin
AU - Golomb, Gershon
AU - Avramoff, Avi
AU - Hoffman, Amnon
PY - 1993/6
Y1 - 1993/6
N2 - High molecular weight drugs in general, and peptides in particular, are usually delivered by parenteral route because they are poorly absorbed or degraded in the gastrointestinal tract. To optimize therapy, it is desirable to search for nonparenteral routes of administration and to deliver the drug in a controlled-release fashion. We report here on the absorption and the systemic biological effect of two peptides, insulin and calcitonin, after instillation into the uterus of the rat. Intrauterine delivery was compared to subcutaneous injections in intact and ovariectomized rats. In addition, we describe results of a preliminary study on calcitonin absorption from controlled-release matrices inserted in the rat uterus. The amount and duration of the hypoglycemic and the hypocalcemic effects induced by intrauterine delivery of insulin and calcitonin, respectively, were equivalent to those obtained after subcutaneous injections. The results were similar in intact and ovariectomized rats. It is concluded that the intrauterine administration of both insulin and calcitonin is bioequivalent to subcutaneous injection. The therapy of a number of clinically important diseases could benefit from this discovery.
AB - High molecular weight drugs in general, and peptides in particular, are usually delivered by parenteral route because they are poorly absorbed or degraded in the gastrointestinal tract. To optimize therapy, it is desirable to search for nonparenteral routes of administration and to deliver the drug in a controlled-release fashion. We report here on the absorption and the systemic biological effect of two peptides, insulin and calcitonin, after instillation into the uterus of the rat. Intrauterine delivery was compared to subcutaneous injections in intact and ovariectomized rats. In addition, we describe results of a preliminary study on calcitonin absorption from controlled-release matrices inserted in the rat uterus. The amount and duration of the hypoglycemic and the hypocalcemic effects induced by intrauterine delivery of insulin and calcitonin, respectively, were equivalent to those obtained after subcutaneous injections. The results were similar in intact and ovariectomized rats. It is concluded that the intrauterine administration of both insulin and calcitonin is bioequivalent to subcutaneous injection. The therapy of a number of clinically important diseases could benefit from this discovery.
KW - absorption
KW - calcitonin
KW - controlled release
KW - drug administration
KW - drug delivery
KW - drug implants
KW - insulin
KW - intrauterine
KW - peptides
UR - http://www.scopus.com/inward/record.url?scp=0027155556&partnerID=8YFLogxK
U2 - 10.1023/A:1018948924992
DO - 10.1023/A:1018948924992
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C2 - 8321850
AN - SCOPUS:0027155556
SN - 0724-8741
VL - 10
SP - 828
EP - 833
JO - Pharmaceutical Research
JF - Pharmaceutical Research
IS - 6
ER -