A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum

Avital Torres; Malka Hochberg; Inna Pergament; Reem Smoum; Valerie Niddam; Valery M. Dembitsky; Marina Temina; Inka Dor; Ovadia Lev; Morris Srebnik; Claes D. Enk

doi:10.1111/j.1432-1033.2004.03981.x

A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum

Avital Torres, Malka Hochberg, Inna Pergament, Reem Smoum, Valerie Niddam, Valery M. Dembitsky, Marina Temina, Inka Dor, Ovadia Lev, Morris Srebnik^*, Claes D. Enk

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.

Original language	English
Pages (from-to)	780-784
Number of pages	5
Journal	European Journal of Biochemistry
Volume	271
Issue number	4
DOIs	https://doi.org/10.1111/j.1432-1033.2004.03981.x
State	Published - Feb 2004

Keywords

Collema cristatum
Lichenized ascomycete
Mycosporine
Photo protective activity
UV-B

Access to Document

10.1111/j.1432-1033.2004.03981.x

Cite this

@article{ee80bd929e994e478f7d7849678674c0,

title = "A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum",

abstract = "A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.",

keywords = "Collema cristatum, Lichenized ascomycete, Mycosporine, Photo protective activity, UV-B",

author = "Avital Torres and Malka Hochberg and Inna Pergament and Reem Smoum and Valerie Niddam and Dembitsky, {Valery M.} and Marina Temina and Inka Dor and Ovadia Lev and Morris Srebnik and Enk, {Claes D.}",

year = "2004",

month = feb,

doi = "10.1111/j.1432-1033.2004.03981.x",

language = "אנגלית",

volume = "271",

pages = "780--784",

journal = "European Journal of Biochemistry",

issn = "0014-2956",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

TY - JOUR

T1 - A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum

AU - Torres, Avital

AU - Hochberg, Malka

AU - Pergament, Inna

AU - Smoum, Reem

AU - Niddam, Valerie

AU - Dembitsky, Valery M.

AU - Temina, Marina

AU - Dor, Inka

AU - Lev, Ovadia

AU - Srebnik, Morris

AU - Enk, Claes D.

PY - 2004/2

Y1 - 2004/2

N2 - A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.

AB - A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.

KW - Collema cristatum

KW - Lichenized ascomycete

KW - Mycosporine

KW - Photo protective activity

KW - UV-B

UR - http://www.scopus.com/inward/record.url?scp=10744221622&partnerID=8YFLogxK

U2 - 10.1111/j.1432-1033.2004.03981.x

DO - 10.1111/j.1432-1033.2004.03981.x

M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???

C2 - 14764094

AN - SCOPUS:10744221622

SN - 0014-2956

VL - 271

SP - 780

EP - 784

JO - European Journal of Biochemistry

JF - European Journal of Biochemistry

IS - 4

ER -

A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum

Abstract

Keywords

Access to Document

Other files and links

Fingerprint

Cite this