A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum

Avital Torres, Malka Hochberg, Inna Pergament, Reem Smoum, Valerie Niddam, Valery M. Dembitsky, Marina Temina, Inka Dor, Ovadia Lev, Morris Srebnik*, Claes D. Enk

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.

Original languageAmerican English
Pages (from-to)780-784
Number of pages5
JournalEuropean Journal of Biochemistry
Volume271
Issue number4
DOIs
StatePublished - Feb 2004

Keywords

  • Collema cristatum
  • Lichenized ascomycete
  • Mycosporine
  • Photo protective activity
  • UV-B

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