A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum

Avital Torres; Malka Hochberg; Inna Pergament; Reem Smoum; Valerie Niddam; Valery M. Dembitsky; Marina Temina; Inka Dor; Ovadia Lev; Morris Srebnik; Claes D. Enk

doi:10.1111/j.1432-1033.2004.03981.x

A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum

Avital Torres
, Malka Hochberg
, Inna Pergament
, Reem Smoum
, Valerie Niddam
, Valery M. Dembitsky
, Marina Temina
, Inka Dor
, Ovadia Lev
, Morris Srebnik^*
, Claes D. Enk

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.

Original language	English
Pages (from-to)	780-784
Number of pages	5
Journal	European Journal of Biochemistry
Volume	271
Issue number	4
DOIs	https://doi.org/10.1111/j.1432-1033.2004.03981.x
State	Published - Feb 2004

Keywords

Collema cristatum
Lichenized ascomycete
Mycosporine
Photo protective activity
UV-B

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10.1111/j.1432-1033.2004.03981.x

Cite this

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title = "A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum",

abstract = "A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.",

keywords = "Collema cristatum, Lichenized ascomycete, Mycosporine, Photo protective activity, UV-B",

author = "Avital Torres and Malka Hochberg and Inna Pergament and Reem Smoum and Valerie Niddam and Dembitsky, \{Valery M.\} and Marina Temina and Inka Dor and Ovadia Lev and Morris Srebnik and Enk, \{Claes D.\}",

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doi = "10.1111/j.1432-1033.2004.03981.x",

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AU - Torres, Avital

AU - Hochberg, Malka

AU - Pergament, Inna

AU - Smoum, Reem

AU - Niddam, Valerie

AU - Dembitsky, Valery M.

AU - Temina, Marina

AU - Dor, Inka

AU - Lev, Ovadia

AU - Srebnik, Morris

AU - Enk, Claes D.

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AB - A novel photo protective mycosporine was isolated from the lichenized ascomycete Collema cristatum. Biological activity was measured in terms of protection against UV-B induced membrane destruction and pyrimidine dimer formation in cultured human keratinocytes, and prevention of UV-B induced erythema. It was found that the pure isolated compound prevented UV-B induced cell destruction in a dose-dependent manner, that the compound partially prevented pyrimidine dimer formation and completely prevented UV-B induced erythema when applied to the skin prior to irradiation.

KW - Collema cristatum

KW - Lichenized ascomycete

KW - Mycosporine

KW - Photo protective activity

KW - UV-B

UR - https://www.scopus.com/pages/publications/10744221622

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SN - 0014-2956

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JO - European Journal of Biochemistry

JF - European Journal of Biochemistry

IS - 4

ER -

A new UV-B absorbing mycosporine with photo protective activity from the lichenized ascomycete Collema cristatum

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