A novel day blindness in sheep: Epidemiological, behavioural, electrophysiological and histopathological studies

Merav H. Shamir, Ron Ofri, Amir Bor, Ori Brenner, Shay Reicher, Alexey Obolensky, Edward Averbukh, Eyal Banin, Elisha Gootwine*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Four genetically related Improved Awassi sheep flocks had sporadic births of lambs with congenital visual impairments that differed from other known forms of sheep blindness. Pedigree analysis suggested an autosomal recessive mode of inheritance. Behavioural studies of 4-month old affected lambs showed that their day vision (but not night vision) was impaired. Electrophysiological results at this age demonstrated diminished function of cones but not rods. Histopathological and immunohistochemical evaluation of affected retinas from 5-month old lambs revealed both red-green and blue cones, suggesting that the behavioural day blindness and reduced cone electroretinograms reflect cone dysfunction rather than severe cone photoreceptor loss. Awassi day blindness may be a form of achromatopsia.

Original languageAmerican English
Pages (from-to)130-137
Number of pages8
JournalVeterinary Journal
Volume185
Issue number2
DOIs
StatePublished - Aug 2010

Bibliographical note

Funding Information:
The authors thank the devoted team at Ein Harod for their continuing collaboration and the Binational Agricultural Research and Development (BARD) fund for financial support.

Keywords

  • Achromatopsia
  • Awassi sheep
  • Day blindness

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