A novel functional infrared imaging system coupled with multiparametric computerised analysis for risk assessment of breast cancer

Tamar Sella*, Miri Sklair-Levy, Maya Cohen, Mona Rozin, Myra Shapiro-Feinberg, Tanir M. Allweis, Eugene Libson, David Izhaky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Objective: We evaluated a functional three-dimensional (3D) infrared imaging system (3DIRI) coupled with multiparametric computer analysis for risk assessment of breast cancer. The technique provides objective risk assessment for the presence of a malignant tumour based on automated parameters derived from a clinically known training set. Methods: Following institutional review board approval, we recruited 434 women for this prospective multicentre trial, including 256 healthy woman undergoing routine screening mammography with BI-RADS-1 results and 178 women with newly diagnosed breast cancer. This was a two-phase study: an initial training and calibration phase, followed by a two-armed blinded evaluation phase (52 healthy and 66 with breast cancer). 3DIRI data sets were acquired using a non-contact, no radiation system. Results: The sensitivity and specificity of functional infrared imaging in providing the correct risk for the presence of breast cancer were 90.9 % and 72.5 %, respectively. The area under the ROC curve was 86 %. Forty-two of the 60 (70 %) cancers in women correctly classified by the system as suspicious were smaller than 20 mm in size. Conclusion: The preliminary blinded results of this novel technology show sufficient performance of functional infrared imaging in providing risk assessment for breast cancer to warrant further clinical studies. Key Points: • 3D functional infrared imaging (3DIRI) provides new metabolic signatures from breast lesions. • 3DIRI offers high sensitivity for risk assessment of breast cancer. • It also has reasonable specificity. • This initial experience warrants further evaluation in larger clinical trials.

Original languageAmerican English
Pages (from-to)1191-1198
Number of pages8
JournalEuropean Radiology
Volume23
Issue number5
DOIs
StatePublished - May 2013
Externally publishedYes

Bibliographical note

Funding Information:
This works was supported by Real Imaging Ltd. which has built the RUTH prototype. T. Sella MD received consulting fees from Real Imaging Ltd. E. Libson MD FRCR received consulting fees from Real Imaging Ltd., D. Izhaky is an employee of Real Imaging Ltd.

Keywords

  • Breast neoplasm
  • Functional imaging
  • Infrared imaging
  • ROC analysis
  • Vascular maps

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