A novel in vivo model in guinea pigs for dry skin syndrome

Assaf Eliezer Sagiv, Arieh Ingber, Shabtay Dikstein*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Background/aims: The lack of a suitable, validated animal model for the comparison of the pharmacological effectiveness of known and potential moisturizers in the treatment of ″dry skin syndrome″ led us to develop such an in vivo model. Methods: ″Dry skin syndrome″ was induced in guinea pigs by daily application of 2 sodium lauryl sulphate (SLS) in deionized water on one of the two shaved flanks for three consecutive days. After ascertaining skin dryness, that side was treated with an agent for 6 days. The in vivo humectant effect was measured by a Corneometer CM 825®, erythema was measured by a Mexameter MX 16®. In some cases histological studies were carried out. Results: The treatment with the 2 SLS led to a consistent ″dry skin syndrome″ for 2 weeks. Glycerol, Vaseline, urea and ammonium lactate treatments validated the model, since the Corneometer CM 825® readings of the treated dry side was equal to ameter MX 16® measurements showed abolishment of the erythema by glycerol only. Histological study showed that SLS treatment creates acanthosis that is partially reversed by Vaseline and fully reversed by glycerol treatment. Conclusion: The guinea pig dry skin model is a relevant model of the human ″dry skin syndrome″. The instrumental results combined with the histological findings indicate that erythema measurements are relevant for the determination of curative effect. (C) Munksgaard, 2000.

Original languageEnglish
Pages (from-to)37-42
Number of pages6
JournalSkin Research and Technology
Volume6
Issue number1
DOIs
StatePublished - Feb 2000

Keywords

  • Dry skin syndrome
  • Guinea pig
  • Moisturizers
  • Sodium lauryl sulphate (SLS)

Fingerprint

Dive into the research topics of 'A novel in vivo model in guinea pigs for dry skin syndrome'. Together they form a unique fingerprint.

Cite this