TY - JOUR
T1 - A novel liposomal influenza vaccine (INFLUSOME-VAC) containing hemagglutinin-neuraminidase and IL-2 or GM-CSF induces protective anti-neuraminidase antibodies cross-reacting with a wide spectrum of influenza A viral strains
AU - Babai, Ilan
AU - Barenholz, Yechezkel
AU - Zakay-Rones, Zichria
AU - Greenbaum, Evgenia
AU - Samira, Sarit
AU - Hayon, Igal
AU - Rochman, Mark
AU - Kedar, Eli
PY - 2001/11/12
Y1 - 2001/11/12
N2 - A liposomal influenza vaccine (INFLUSOME-VAC) was developed with the objective of overcoming the major drawbacks of the currently used influenza vaccines: their relatively low efficacy in certain high-risk groups (the elderly, infants, the immunosuppressed) and the need for annual immunization. INFLUSOME-VAC consists of liposomes containing the viral surface proteins hemagglutinin (HA) and neuraminidase (NA) derived from various influenza strains and IL-2 or GM-CSF, as an adjuvant. Vaccination of mice showed that, whereas conventional vaccines induced a low- and short-term response against HA and very low or no anti-NA response, INFLUSOME-VAC produced high titers of both anti-HA and anti-NA antibodies (Abs) in young and old mice that persisted for at least 6 months. Moreover, the anti-NA Abs efficiently cross-reacted with several N2 viral subtypes spanning 20 years, and such vaccines afforded partial protection against heterosubtypic viral infection.
AB - A liposomal influenza vaccine (INFLUSOME-VAC) was developed with the objective of overcoming the major drawbacks of the currently used influenza vaccines: their relatively low efficacy in certain high-risk groups (the elderly, infants, the immunosuppressed) and the need for annual immunization. INFLUSOME-VAC consists of liposomes containing the viral surface proteins hemagglutinin (HA) and neuraminidase (NA) derived from various influenza strains and IL-2 or GM-CSF, as an adjuvant. Vaccination of mice showed that, whereas conventional vaccines induced a low- and short-term response against HA and very low or no anti-NA response, INFLUSOME-VAC produced high titers of both anti-HA and anti-NA antibodies (Abs) in young and old mice that persisted for at least 6 months. Moreover, the anti-NA Abs efficiently cross-reacted with several N2 viral subtypes spanning 20 years, and such vaccines afforded partial protection against heterosubtypic viral infection.
KW - Cytokines
KW - Influenza vaccine
KW - Liposomes
KW - Neuraminidase
UR - http://www.scopus.com/inward/record.url?scp=0035851359&partnerID=8YFLogxK
U2 - 10.1016/S0264-410X(01)00326-7
DO - 10.1016/S0264-410X(01)00326-7
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C2 - 11672916
AN - SCOPUS:0035851359
SN - 0264-410X
VL - 20
SP - 505
EP - 515
JO - Vaccine
JF - Vaccine
IS - 3-4
ER -