A novel method for the facile synthesis of depsipeptides

Chaim Gilon*, Yakir Klausner, Alfred Hassner

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

A one pot, high yield synthesis of depsipeptides is described involving room temperature condensation of hindered substrates (N-Boc amino acids and benzyl α-hydroxy esters) in the presence of DCC and a dialkylaminopyridine. In this manner previously inaccessible depsipeptides were prepared.

Original languageEnglish
Pages (from-to)3811-3814
Number of pages4
JournalTetrahedron Letters
Volume20
Issue number40
DOIs
StatePublished - 1979

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