A novel mitochondrial septin-like protein, ARTS, mediates apoptosis dependent on its P-loop motif

Sarit Larisch, Youngsuk Yi, Rona Lotan, Hedviga Kerner, Sarah Eimerl, W. Tony Parks, Yossi Gottfried, Stephanie Birkey Reffey, Mark P. De Caestecker, David Danielpour, Naomi Book-Melamed, Rina Timberg, Colin S. Duckett, Robert J. Lechleider, Hermann Steller, Joseph Orly, Seong Jin Kim, Anita B. Roberts*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

212 Scopus citations

Abstract

Here we describe a protein product of the human septin H5/PNUTL2/CDCrel2b gene, which we call ARTS (for apoptosis-related protein in the TGF-β signalling pathway). ARTS is expressed in many ceils and acts to enhance cell death induced by TGF-β or, to a lesser extent, by other apoptotic agents. Unlike related septin gene products, ARTS is localized to mitochondria and translocates to the nucleus when apoptosis occurs. Mutation of the P-loop of ARTS abrogates its competence to activate caspase 3 and to induce apoptosis. Taken together, these observations expand the functional attributes of septins previously described as having roles in cytokinesis and cellular morphogenesis.

Original languageEnglish
Pages (from-to)915-921
Number of pages7
JournalNature Cell Biology
Volume2
Issue number12
DOIs
StatePublished - 2000

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