TY - JOUR
T1 - A novel nonpsychotropic cannabinoid, HU-211, in the treatment of experimental pneumococcal meningitis
AU - Bass, Roman
AU - Engelhard, Dan
AU - Trembovler, Victoria
AU - Shohami, Esther
PY - 1996
Y1 - 1996
N2 - Typical features of pneumococcal meningitis have been demonstrated in rats inoculated with Streptococcus pneumoniae. HU-211, a novel noncompetitive N- methyl-D-aspartate antagonist recently demonstrated to inhibit tumor necrosis factor-α production under various conditions, improves recovery in some experimental models of brain injury. The present study tested the efficacy of HU-211 in combination with antimicrobial therapy in reducing brain damage in experimental pneumococcal meningitis. S. pneumoniae-infected rats were treated with saline alone, ceftriaxone alone, or with a combination of ceftriaxone and HU-211 18 h after inoculation of the bacteria. Brain edema and blood-brain barrier impairment 48 h after infection were significantly (P < .05) reduced in rats treated with ceftriaxone-HU-211 compared with rats in other treatment groups. The results suggest that HU-211 when given concomitantly with antibiotics attenuates brain damage in the rat model of pneumococcal meningitis.
AB - Typical features of pneumococcal meningitis have been demonstrated in rats inoculated with Streptococcus pneumoniae. HU-211, a novel noncompetitive N- methyl-D-aspartate antagonist recently demonstrated to inhibit tumor necrosis factor-α production under various conditions, improves recovery in some experimental models of brain injury. The present study tested the efficacy of HU-211 in combination with antimicrobial therapy in reducing brain damage in experimental pneumococcal meningitis. S. pneumoniae-infected rats were treated with saline alone, ceftriaxone alone, or with a combination of ceftriaxone and HU-211 18 h after inoculation of the bacteria. Brain edema and blood-brain barrier impairment 48 h after infection were significantly (P < .05) reduced in rats treated with ceftriaxone-HU-211 compared with rats in other treatment groups. The results suggest that HU-211 when given concomitantly with antibiotics attenuates brain damage in the rat model of pneumococcal meningitis.
UR - http://www.scopus.com/inward/record.url?scp=0030041950&partnerID=8YFLogxK
U2 - 10.1093/infdis/173.3.735
DO - 10.1093/infdis/173.3.735
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C2 - 8627042
AN - SCOPUS:0030041950
SN - 0022-1899
VL - 173
SP - 735
EP - 738
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 3
ER -
