TY - JOUR
T1 - A novel role of topical iodine in skin
T2 - Activation of the Nrf2 pathway
AU - Ben-Yehuda Greenwald, Maya
AU - Frušić-Zlotkin, Marina
AU - Soroka, Yoram
AU - Ben-Sasson, Shmuel
AU - Bianco-Peled, Havazelet
AU - Kohen, Ron
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/3/1
Y1 - 2017/3/1
N2 - For a long time iodine has been used as an active dermal agent in the treatment of inflammatory, immune-mediated and infectious diseases. Moreover, topical iodine application has been reported to provide protection against sulfur-mustard-induced skin lesions, heat-induced and acid-induced skin burns in both haired guinea-pigs and mouse ear swelling models. However, the exact mechanism of action underlying these benefits of iodine has not yet been elucidated. In the current study, a novel mechanism of action by which iodine provides skin protection and relief, based on its electrophilic nature, is suggested. This study demonstrates that both iodine and iodide are capable of activating the Nrf2 pathway in human skin. As a result, skin protection against UVB-induced damage was acquired and the secretion of pro-inflammatory cytokines (IL-6, IL-8) from LPS-challenged skin was reduced. Iodide role in the enhanced activation of this pathway is demonstrated. The mode of action by which iodine and iodide activate the Nrf2 pathway is discussed.
AB - For a long time iodine has been used as an active dermal agent in the treatment of inflammatory, immune-mediated and infectious diseases. Moreover, topical iodine application has been reported to provide protection against sulfur-mustard-induced skin lesions, heat-induced and acid-induced skin burns in both haired guinea-pigs and mouse ear swelling models. However, the exact mechanism of action underlying these benefits of iodine has not yet been elucidated. In the current study, a novel mechanism of action by which iodine provides skin protection and relief, based on its electrophilic nature, is suggested. This study demonstrates that both iodine and iodide are capable of activating the Nrf2 pathway in human skin. As a result, skin protection against UVB-induced damage was acquired and the secretion of pro-inflammatory cytokines (IL-6, IL-8) from LPS-challenged skin was reduced. Iodide role in the enhanced activation of this pathway is demonstrated. The mode of action by which iodine and iodide activate the Nrf2 pathway is discussed.
KW - Electrophiles
KW - Iodine
KW - Nrf2
KW - Oxidants
KW - Oxidative stress
KW - Phase-II enzymes
KW - Potassium iodide
KW - Skin
UR - http://www.scopus.com/inward/record.url?scp=85009861498&partnerID=8YFLogxK
U2 - 10.1016/j.freeradbiomed.2017.01.011
DO - 10.1016/j.freeradbiomed.2017.01.011
M3 - ???researchoutput.researchoutputtypes.contributiontojournal.article???
C2 - 28088623
AN - SCOPUS:85009861498
SN - 0891-5849
VL - 104
SP - 238
EP - 248
JO - Free Radical Biology and Medicine
JF - Free Radical Biology and Medicine
ER -